Phần 3: Nghiên cứu sinh học phân tử trên các loại sán lá, đơn bào và mối liên quan đến ung thư cơ quan ở người

Trong bối cảnh biến đổi khí hậu toàn cầu (Global Climate change), nhiều bệnh truyền nhiễm đang nổi và tái nổi có xu hướng tăng lên đáng kể và đe dọa tử vong cũng như gia tăng gánh nặng bệnh tật toàn cầu. Trong đó một số bệnh ký sinh trùng và đơn bào có liên quan có ý nghĩa với một số bệnh ung thư như sán lá gan nhỏ Opisthorchis viverrini, Clonorchis sinensis liên quan đến ung thư biểu mô đường mật (cholangiocarcinoma), hay sán máng Schitosoma haematobium liên quan ung thư bàng quan tiết niệu, hay Cryptosporidium parvum có liên quan đến ung thư đại trực tràng (colorectal cancer).

Bên cạnh đó, việc xác định loài các giun sán về mặt hình thái học và sinh học phân tử phần nào làm rõ về phả hệ di truyền của các loài ký sinh trùng gây bệnh ở người. Các nghiên cứu sau đây làm rõ các vấn đề mà gần đây các nhà khoa học đang quan tâm làm rõ.

Egg‐hatching mechanism of human liver fluke, opisthorchis viverrini: a role for leucine aminopeptidases from the snail host, bithynia siamensis goniomphalos.

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Low Divergence of Clonorchis sinensis in China Based o­n Multilocus Analysis.

Sun J, Huang Y, Huang H, Liang P, Wang X, Mao Q, Men J, Chen W, Deng C, Zhou C, Lv X, Zhou J, Zhang F, Li R, Tian Y, Lei H, Liang C, Hu X, Xu J, Li X, Xinbingyu.

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Functional Analysis of the Unique Cytochrome P450 of the Liver Fluke Opisthorchis felineus.

Pakharukova MY, Vavilin VA, Sripa B, Laha T, Brindley PJ, Mordvinov VA.

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The draft genome of the carcinogenic human liver fluke Clonorchis sinensis.

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Hình 2

Resistance of cholangiocarcinoma cells to parthenolide‐induced apoptosis by the excretory‐secretory products of Clonorchis sinensis.

Kim YJ, Choi MH, Hong ST, Bae YM.

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Improved genomic resources and new bioinformatic workflow for the carcinogenic parasite Clonorchis sinensis: Biotechnological implications.

Wang D, Korhonen PK, Gasser RB, Young ND.

Biotechnol Adv. 2018 Jul ‐ Aug;36(4):894‐904. doi: 10.1016/j.biotechadv.2018.02.008. Epub 2018 Feb 15. Review.

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Discrimination of tiger using a novel high resolution melting (HRM) and multiplex SNP‐specific HRM (MSS‐HRM) technique.

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Forensic Sci Int Genet. 2014 Nov;13:30‐3. doi: 10.1016/j.fsigen.2014.07.001. Epub 2014 Jul 10. No abstract available.

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Temperature dependence of Opisthorchis viverrini infection in first intermediate host snail, Bithynia siamensis goniomphalos.

Prasopdee S, Kulsantiwong J, Piratae S, Khampoosa P, Thammasiri C, Suwannatrai A, Laha T, Grams R, Loukas A, Tesana S.

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[A man in his thirties with icterus and itching].

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Clonorchis sinensis omega‐class glutathione transferases are reliable biomarkers for serodiagnosis of clonorchiasis and opisthorchiasis.

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Schistosome and liver fluke derived catechol‐estrogens and helminth associated cancers.

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Food‐borne trematodiases in Southeast Asia epidemiology, pathology, clinical manifestation and control.

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Phylogenetic relationships within the Opisthorchis viverrini species complex with specific analysis of O. viverrini sensu lato from Sakon Nakhon, Thailand by mitochondrial and nuclear DNA sequencing.

Pitaksakulrat O, Webster BL, Webster JP, Laha T, Saijuntha W, Lamberton PHL, Kiatsopit N, Andrews RH, Petney TN, Sithithaworn P.

Infect Genet Evol. 2018 Apr 19;62:86‐94. doi: 10.1016/j.meegid.2018.04.022. [Epub ahead of print]

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Molecular and Biochemical Characterization of Opisthorchis viverrini Calreticulin.

Chaibangyang W, Geadkaew‐Krenc A, Vichasri‐Grams S, Tesana S, Grams R.

Korean J Parasitol. 2017 Dec;55(6):643‐652. doi: 10.3347/kjp.2017.55.6.643. Epub 2017 Dec 31.

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Infections by Hepatic Trematodes in Cats from Slaughterhouses in Vietnam.

Nguyen HM, Tatonova YV, Madsen H.

J Parasitol. 2018 Mar 9. doi: 10.1645/18‐5. [Epub ahead of print]

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Hình 6

American Association of Veterinary Parasitologists’ review of veterinary fecal flotation methods and factors influencing their accuracy and use‐is there really o­ne best technique?

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Biliary parasites: diagnostic and therapeutic strategies.

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Curr Treat Options Gastroenterol. 2008 Apr;11(2):85‐95.

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Why does infection with some helminths cause cancer?

Brindley PJ, da Costa JM, Sripa B.

Trends Cancer. 2015 Nov 1;1(3):174‐182.

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Why Does Infection With Some Helminths Cause Cancer?

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Hình 7

Nucleotide sequence of the small subunit ribosomal RNA‐encoding gene from Opisthorchis viverrini.

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Gene. 1991 Sep 15;105(2):259‐61.

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Development of high‐resolution melting (HRM) analysis for population studies of Fascioloides magna (Trematoda: Fasciolidae), the giant liver fluke of ruminants.

Radvánský J, Bazsalovicsová E, Králová‐Hromadová I, Minárik G, Kádaši L.

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Rapid and inexpensive species differentiation using a multiplex real‐time polymerase chain reaction high‐resolution melt assay.

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Anal Biochem. 2016 May 1;500:15‐7. doi: 10.1016/j.ab.2016.01.013. Epub 2016 Feb 4.

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Comparative morphology of minute intestinal fluke eggs that can occur in human stools in the republic of Korea.

Lee JJ, Jung BK, Lim H, Lee MY, Choi SY, Shin EH, Chai JY.

Korean J Parasitol. 2012 Sep;50(3):207‐13. doi: 10.3347/kjp.2012.50.3.207. Epub 2012 Aug 13.

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Hình 8

Trematodes of the family Opisthorchiidae: a minireview.

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Korean J Parasitol. 2001 Sep;39(3):209‐21. Review.

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Genererating a core cluster of Fasciola hepatica virulence and immunomodulation‐related genes using a comparative in silico approach.

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Res Vet Sci. 2018 Apr;117:271‐276. doi: 10.1016/j.rvsc.2017.12.023. Epub 2017 Dec 28.

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Study o­n the surface morphology of the developmental stages of the liver fluke, Opisthorchis viverrini (Trematoda: Opisthorchiidae).

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Egg production of Clonorchis sinensis in different strains of inbred mice.

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Kisaengchunghak Chapchi. 1992 Sep;30(3):169‐75.

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Hình 9

Multiplex genotyping based o­n the melting temperature of a single locked nucleic acid probe.

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Anal Biochem. 2015 Dec 15;491:72‐4. doi: 10.1016/j.ab.2015.09.007. Epub 2015 Sep 16.

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Isozyme electrophoresis patterns of the liver fluke, Clonorchis sinensis from Kimhae, Korea and from Shenyang, China.

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Low genetic diversity in wide‐spread Eurasian liver fluke Opisthorchis felineus suggests special demographic history of this trematode species.

Brusentsov II, Katokhin AV, Brusentsova IV, Shekhovtsov SV, Borovikov SN, Goncharenko GG, Lider LA, Romashov BV, Rusinek OT, Shibitov SK, Suleymanov MM, Yevtushenko AV, Mordvinov VA.

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Parasites and malignancies, a review, with emphasis o­n digestive cancer induced by Cryptosporidium parvum (Alveolata: Apicomplexa).

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Hình 10

Two alternative multiplex PCRs for the identification of the seven species of anglerfish (Lophius spp.) using an end‐point or a melting curve analysis real‐time protocol.

Castigliego L, Armani A, Tinacci L, Gianfaldoni D, Guidi A.

Food Chem. 2015 Jan 1;166:1‐9. doi: 10.1016/j.foodchem.2014.06.014. Epub 2014 Jun 12.

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Biliary cystadenoma associated with Opisthorchis viverrini infection in a domestic cat (Felis catus).

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Vet Parasitol. 2018 May 5. pii: S0304‐4017(18)30158‐4. doi: 10.1016/j.vetpar.2018.05.001. [Epub ahead of print]

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Comparative Characterization of Four Calcium‐Binding EF Hand Proteins from Opisthorchis viverrini.

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Hình 11

Haemoptysis and transitory lung‐infiltrations associated with clonorchis sinensis.

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Beitr Klin Erforsch Tuberk Lungenkr. 1967;134(4):259‐64. No abstract available.

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Development of a direct PCR assay to detect Taenia multiceps eggs isolated from dog feces.

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A real‐time qPCR assay to quantify Ophiocordyceps sinensis biomass in Thitarodes larvae.

Lei W, Li S, Peng Q, Zhang G, Liu X.

J Microbiol. 2013 Apr;51(2):229‐33. doi: 10.1007/s12275‐013‐2241‐7. Epub 2013 Apr 27.

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Hình 11

Carcinogenesis associated with parasites other than Schistosoma, Opisthorchis and Clonorchis: A systematic review.

Machicado C, Marcos LA.

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Cell‐Free Expression and In Situ Immobilization of Parasite Proteins from Clonorchis sinensis for Rapid Identification of Antigenic Candidates.

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Molecular screening and predation evaluation of the key predators of Conopomorpha sinensis Bradley (Lepidoptera: Gracilariidae) in litchi orchards.

Meng X, Ouyang GC, Liu H, Hou BH, Huang SS, Guo MF.

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Hình 12

Development of a simultaneous identification method for 13 animal species using two multiplex real‐time PCR assays and melting curve analysis.

Ishida N, Sakurada M, Kusunoki H, Ueno Y.

Leg Med (Tokyo). 2018 Jan;30:64‐71. doi: 10.1016/j.legalmed.2017.11.007. Epub 2017 Nov 26.

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The high resolution melting analysis (HRM) as a molecular tool for monitoring parasites of the wildlife.

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Parasitology. 2017 Apr;144(5):563‐570. doi: 10.1017/S0031182016002183. Epub 2016 Dec 12.

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Identification of Chinese Caterpillar Medicinal Mushroom, Ophiocordyceps sinensis (Ascomycetes) from Counterfeit Species.

Zhang W, Zhang X, Li M, Shi Y, Zhang P, Cheng XL, Wei F, Ma S.

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[Development and evaluation of a rapid PCR detection kit for Ophiocordyceps sinensis].

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Zhongguo Zhong Yao Za Zhi. 2017 Mar;42(6):1125‐1129. doi: 10.19540/j.cnki.cjcmm.20170217.011. Chinese.

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Helminths and Cancers From the Evolutionary Perspective.

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Front Med (Lausanne). 2018 Apr 16;5:90. doi: 10.3389/fmed.2018.00090. eCollection 2018. Review.

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KOURI P, BASNUEVO JG, SOTOLONGO F.

Kuba. 1946 Feb;2:26‐36. Undetermined Language. No abstract available.

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Performance evaluation of existing immunoassays for Clonorchis sinensis infection in China.

Li HM, Qian MB, Yang YC, Jiang ZH, Wei K, Chen JX, Chen JH, Chen YD, Zhou XN.

Parasit Vectors. 2018 Jan 15;11(1):35. doi: 10.1186/s13071‐018‐2612‐3.

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Molecular discrimination of Opisthorchis‐like eggs from residents in a rural community of central Thailand.

Buathong S, Leelayoova S, Mungthin M, Ruang‐Areerate T, Naaglor T, Suwannahitatorn P, Piyaraj P, Taamasri P, Tan‐Ariya P.

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LAMPhimerus: A novel LAMP assay for detecting Amphimerus sp. DNA in human stool samples.

Cevallos W, Fernández‐Soto P, Calvopiña M, Fontecha‐Cuenca C, Sugiyama H, Sato M, López Abán J, Vicente B, Muro A.

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Development of a PCR Assay for Diagnosing Trematode (Opisthorchis and Haplorchis) Infections in Human Stools.

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