Phần 2: Nghiên cứu sinh học phân tử trên các loại sán lá, đơn bào và mối liên quan đến ung thư cơ quan ở người

Trong bối cảnh biến đổi khí hậu toàn cầu (Global Climate change), nhiều bệnh truyền nhiễm đang nổi và tái nổi có xu hướng tăng lên đáng kể và đe dọa tử vong cũng như gia tăng gánh nặng bệnh tật toàn cầu. Trong đó một số bệnh ký sinh trùng và đơn bào có liên quan có ý nghĩa với một số bệnh ung thư như sán lá gan nhỏ Opisthorchis viverrini, Clonorchis sinensis liên quan đến ung thư biểu mô đường mật (cholangiocarcinoma), hay sán máng Schitosoma haematobium liên quan ung thư bàng quan tiết niệu, hay Cryptosporidium parvum có liên quan đến ung thư đại trực tràng (colorectal cancer).

Bên cạnh đó, việc xác định loài các giun sán về mặt hình thái học và sinh học phân tử phần nào làm rõ về phả hệ di truyền của các loài ký sinh trùng gây bệnh ở người. Các nghiên cứu sau đây làm rõ các vấn đề mà gần đây các nhà khoa học đang quan tâm làm rõ.

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Specific gravity of Opisthorchis viverrini eggs.

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TaqMan real‐time PCR assay for specific detection of Opisthorchis viverrini DNA in Thai patients with hepatocellular carcinoma and cholangiocarcinoma.

Suksumek N, Leelawat K, Leelawat S, Russell B, Lek‐Uthai U.

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[The outer membranes of the eggs of Opisthorchis felineus and Clonorchis sinensis].

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Nguyen TT, Arimatsu Y, Hong SJ, Brindley PJ, Blair D, Laha T, Sripa B.

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Is Opisthorchis viverrini an avian liver fluke?

Nawa Y, Doanh PN, Thaenkham U.

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Potassium permanganate staining for differentiation the surface morphology of Opisthorchis viverrini, Haplorchis taichui and Phaneropsolus bonnei eggs.

Sukontason K, Piangjai S, Sukontason K, Chaithong U.

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[Research progress o­n the relationship between three kinds of liver fluke infections and cholangiocarcinoma].

Liu GX, Wu XP, Wang ZJ, Bai X, Liu MY.

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Methylene blue staining method for identification of Opisthorchis viverrini egg.

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Extreme conservation of miRNA complements in opisthorchiids.

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Recurrent emergence of structural variants of LTR retrotransposon CsRn1 evolving novel expression strategy and their selective expansion in a carcinogenic liver fluke, Clonorchis sinensis.

Kim SH, Kong Y, Bae YA.

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Immunological analysis of Opisthorchis and Clonorchis antigens.

Sirisinha S, Sahassananda D, Bunnag D, Rim HJ.

J Helminthol. 1990 Jun;64(2):133‐8.

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Chromosomes and karyotype analysis of a liver fluke, Opisthorchis viverrini, by scanning electron microscopy.

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Human infections with liver and minute intestinal flukes in Guangxi, China: analysis by DNA sequencing, ultrasonography, and immunoaffinity chromatography.

Jeon HK, Lee D, Park H, Min DY, Rim HJ, Zhang H, Yang Y, Li X, Eom KS.

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Prevalence of Opisthorchis viverrini infection in humans and fish in Kratie Province, Cambodia.

Sohn WM, Yong TS, Eom KS, Pyo KH, Lee MY, Lim H, Choe S, Jeong HG, Sinuon M, Socheat D, Chai JY.

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Discovery of Opisthorchis lobatus (Trematoda: Opisthorchiidae): a new record of small liver flukes in the Greater Mekong Sub‐region.

Thaenkham U, Nuamtanong S, Vonghachack Y, Yoonuan T, Sanguankiat S, Dekumyoy P, Prommasack B, Kobayashi J, Waikagul J.

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Microsatellite loci in the carcinogenic liver fluke, Opisthorchis viverrini and their application as population genetic markers.

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Detection of Opisthorchis viverrini in human stool specimens by PCR.

Wongratanacheewin S, Pumidonming W, Sermswan RW, Pipitgool V, Maleewong W.

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Molecular characterization of a tetraspanin from the human liver fluke, Opisthorchis viverrini.

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Molecular genetic profiles among individual Clonorchis sinensis adults collected from cats in two geographic regions of China revealed by RAPD and MGE‐PCR methods.

Lai DH, Wang QP, Chen W, Cai LS, Wu ZD, Zhu XQ, Lun ZR.

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A novel, multiplex, real‐time PCR‐based approach for the detection of the commonly occurring pathogenic fungi and bacteria.

Horváth Á, Pető Z, Urbán E, Vágvölgyi C, Somogyvári F.

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Kummalue T, Chuphrom A, Sukpanichanant S, Pongpruttipan T, Sukpanichanant S.

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Tesana S, Srisawangwong T, Sithithaworn P, Itoh M, Phumchaiyothin R.

Ann Trop Med Parasitol. 2007 Oct;101(7):585‐91.

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Genetic relationships within the Opisthorchis viverrini species complex with specific analysis of O. viverrini from Savannakhet, Lao PDR by multilocus enzyme electrophoresis.

Kiatsopit N, Sithithaworn P, Sithithaworn J, Boonmars T, Tesana S, Pitaksakulrat O, Saijuntha W, Petney TN, Andrews RH.

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Pauly A, Schuster R, Steuber S.

Parasitol Res. 2003 Aug;90(5):409‐14. Epub 2003 May 14.

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Molecular changes in Opisthorchis viverrini (Southeast Asian liver fluke) during the transition from the juvenile to the adult stage.

Jex AR, Young ND, Sripa J, Hall RS, Scheerlinck JP, Laha T, Sripa B, Gasser RB.

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[Identification of Clonorchis sinensis metacercariae based o­n PCR targeting ribosomal DNA ITS regions and COX1 gene].

Yang QL, Shen JQ, Jiang ZH, Yang YC, Li HM, Chen YD, Zhou XN.

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Liver fluke infection and cholangiocarcinoma: a review.

Zheng S, Zhu Y, Zhao Z, Wu Z, Okanurak K, Lv Z.

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Opisthorchis viverrini‐like liver fluke in birds from Vietnam: morphological variability and rDNA/mtDNA sequence confirmation.

Dao TH, Nguyen TG, Victor B, Gabriël S, Dorny P.

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Geyer CN, Hanson ND.

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Accuracy of the Kato‐Katz method and formalin‐ether concentration technique for the diagnosis of Clonorchis sinensis, and implication for assessing drug efficacy.

Qian MB, Yap P, Yang YC, Liang H, Jiang ZH, Li W, Utzinger J, Zhou XN, Keiser J.

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Characterization of the antioxidant enzyme, thioredoxin peroxidase, from the carcinogenic human liver fluke, Opisthorchis viverrini.

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Select item 26363139120.

Whole transcriptome profiling of adult and infective stages of the trematode Opisthorchis felineus.

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Microscopic identification of possible Clonorchis/Opisthorchis infection in two Ghanaian women with undiagnosed abdominal discomfort: two case reports.

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Parasite‐Associated Cancers (Blood Flukes/Liver Flukes).

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Multiplex Real‐Time PCR Assay Targeting Eight Parasites Customized to the Korean Population: Potential Use for Detection in Diarrheal Stool Samples from Gastroenteritis Patients.

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