Phần 2: Sốt rét ác tính: nhiều vấn đề liên quan đến cơ chế vẫn chưa sáng tỏ

Nhân loại có 3 kẻ thù quan trọng đó là sốt, đói nghèo và chiến tranh. Trong đó, sốt vẫn được coi là nguy hiểm nhất (“Humanityhasbutthreegreatenemies, Fever,famineandwar:ofthesebyfarthe greatest,byfarthemostterribleisfever ‐William Osler, 1896). Sốt rét vẫn là vấn đề y tế công cộng nghiêm trọng với tỷ lệ mắc và tử vong tiếp tục giữ vị trí cao trong danh sách các bệnh truyền nhiễm.

Sốt rét ác tính (SRAT) là vấn đề cấp cứu y khoa bởi diễn tiến bệnh nhanh với các biến chứng nghiêm trọng, đe dọa tử vong cao cho nhiều bệnh nhân.

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Field evaluation of the ICT Malaria Pf/Pv immunochromatographic test for the detection of asymptomatic malaria in a Plasmodium falciparum/vivax endemic area in Thailand.

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Comparison of PCR and microscopy for the detection of asymptomatic malaria in a Plasmodium falciparum/vivax endemic area in Thailand.

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High Rates of Asymptomatic, Sub-microscopic Plasmodium vivax Infection and Disappearing Plasmodium falciparum Malaria in an Area of Low Transmission in Solomon Islands.

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Prevalence and implications of cerebrospinal fluid leukocytosis in Papua New Guinean children hospitalized with severe malaria.

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Clinical profile of Plasmodium falciparum and Plasmodium vivax infections in low and unstable malaria transmission settings of Colombia.

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Severe Malaria Associated with Plasmodium falciparum and P. vivax among Children in Pawe Hospital, Northwest Ethiopia.

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Do we know enough to find an adjunctive therapy for cerebral malaria in African children?

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Pathophysiology, clinical presentation, and treatment of coma and acute kidney injury complicating falciparum malaria.

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New Syndromes Identified by Neuroimaging during Cerebral Malaria.

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Investigating the Pathogenesis of Severe Malaria: A Multidisciplinary and Cross-Geographical Approach

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Do we know enough to find an adjunctive therapy for cerebral malaria in African children?

Brittany A. Riggle, Louis H. Miller, Susan K. Pierce

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Plasmodium falciparum EPCR-binding PfEMP1 expression increases with malaria disease severity and is elevated in retinopathy negative cerebral malaria

Estela Shabani, Benjamin Hanisch, Robert O. Opoka, Thomas Lavstsen, Chandy C. John

BMC Med. 2017; 15: 183. Published o­nline 2017 Oct 13. doi: 10.1186/s12916‐017‐0945‐y

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Complicated malaria in children and adults from three settings of the Colombian Pacific Coast: A prospective study

Myriam Arévalo‐Herrera, Lina Rengifo, Mary Lopez‐Perez, Maria I. Arce‐Plata, Jhon García, Sócrates Herrera

PLoS o­ne. 2017; 12(9): e0185435. Published o­nline 2017 Sep 25. doi: 10.1371/journal.pone.0185435

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Characterization of P. vivax blood stage transcriptomes from field isolates reveals similarities among infections and complex gene isoforms

Adam Kim, Jean Popovici, Amélie Vantaux, Reingsey Samreth, Sophalai Bin, Saorin Kim, Camille Roesch, Li Liang, Huw Davies, Philip Felgner, Sócrates Herrera, Myriam Arévalo‐Herrera, Didier Ménard, David Serre

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Single-molecule analysis reveals that DNA replication dynamics vary across the course of schizogony in the malaria parasite Plasmodium falciparum

Slavica Stanojcic, Nada Kuk, Imran Ullah, Yvon Sterkers, Catherine J. Merrick

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Case Report: Severe and Complicated Cynomolgi Malaria in a Rhesus Macaque Resulted in Similar Histopathological Changes as Those Seen in Human Malaria

Chester J. Joyner, The MaHPIC Consortium, Jennifer S. Wood, Alberto Moreno, Anapatricia Garcia, Mary R. Galinski

Am J Trop Med Hyg. 2017 Aug 2; 97(2): 548‐555. Published o­nline 2017 Jun 5. doi: 10.4269/ajtmh.16‐0742

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Epidemiology of Plasmodium vivax Malaria in India

Anupkumar R. Anvikar, Naman Shah, Akshay C. Dhariwal, Gagan Singh Sonal, Madan Mohan Pradhan, Susanta K. Ghosh, Neena Valecha

Am J Trop Med Hyg. 2016 Dec 28; 95(6 Suppl): 108‐120. doi: 10.4269/ajtmh.16‐0163

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EPCR and malaria severity: the center of a perfect storm

Maria Bernabeu, Joseph D. Smith

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Exploring experimental cerebral malaria pathogenesis through the characterisation of host-derived plasma microparticle protein content

Natalia Tiberti, Sharissa L. Latham, Stephen Bush, Amy Cohen, Robert O. Opoka, Chandy C. John, Annette Juillard, Georges E. Grau, Valéry Combes

Sci Rep. 2016; 6: 37871. Published o­nline 2016 Dec 5. doi: 10.1038/srep37871

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Pharmacogenomic implications of the evolutionary history of infectious diseases in Africa

J L Baker, D Shriner, A R Bentley, C N Rotimi

Pharmacogenomics J. 2017 Mar; 17(2): 112‐120. Published o­nline 2016 Oct 25. doi: 10.1038/tpj.2016.78

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Natural Mosquito-Pathogen Hybrid IgG4 Antibodies in Vector-Borne Diseases: A Hypothesis

Berlin Londono‐Renteria, Jenny C. Cardenas, Andrea Troupin, Tonya M. Colpitts

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Severe malaria: what’s new o­n the pathogenesis front?

Samuel Crocodile Wassmer, Georges Emile Raymond Grau

Int J Parasitol. Author manuscript; available in PMC 2018 Feb 1.

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Plasmodium falciparum var genes expressed in children with severe malaria encode CIDRα1 domains

Jakob S Jespersen, Christian W Wang, Sixbert I Mkumbaye, Daniel TR Minja, Bent Petersen, Louise Turner, Jens EV Petersen, John PA Lusingu, Thor G Theander, Thomas Lavstsen

EMBO Mol Med. 2016 Aug; 8(8): 839‐850. Published o­nline 2016 Jun 27. doi: 10.15252/emmm.201606188

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Tying malaria and microRNAs: from the biology to future diagnostic perspectives

Mercedes Rubio, Quique Bassat, Xavier Estivill, Alfredo Mayor

Malar J. 2016; 15: 167. Published o­nline 2016 Mar 15. doi: 10.1186/s12936‐016‐1222‐9

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Cardiovascular changes in patients with non-severe Plasmodium vivax malaria

Aristoteles Comte Alencar‐Filho, Joao Marcos Bemfica Barbosa Ferreira, Jorge Luis Salinas, Camila Fabbri, Wuelton Marcelo Monteiro, Andre Machado Siqueira, Katashi Okoshi, Marcus Vinicius Guimaraes Lacerda, Marina Politi Okoshi

Int J Cardiol Heart Vasc. 2016 Jun; 11: 12‐16. Published o­nline 2016 Mar 10. doi: 10.1016/j.ijcha.2016.03.004

PMCID: PMC5441355 Article PubReader PDF–255KCitation

Transfection with thymidine kinase permits bromodeoxyuridine labelling of DNA replication in the human malaria parasite Plasmodium falciparum

Catherine J. Merrick

Malar J. 2015; 14: 490. Published o­nline 2015 Dec 2. doi: 10.1186/s12936‐015‐1014‐7

PMCID: PMC4668656 Article PubReader PDF–1.5MCitation

Glycophorins, blood groups, and protection from severe malaria

Samuel C. Wassmer, Jane M. Carlton

Trends Parasitol. Author manuscript; available in PMC 2017 Jan 1.

Published in final edited form as: Trends Parasitol. 2016 Jan; 32(1): 5‐7. Published o­nline 2015 Nov 21. doi: 10.1016/j.pt.2015.11.006

PMCID: PMC4713327 Article PubReader PDF–439KCitation

Pathogenesis of cerebral malaria: new diagnostic tools, biomarkers, and therapeutic approaches

Praveen K. Sahu, Sanghamitra Satpathi, Prativa K. Behera, Saroj K. Mishra, Sanjib Mohanty, Samuel Crocodile Wassmer

Front Cell Infect Microbiol. 2015; 5: 75. Published o­nline 2015 Oct 27. doi: 10.3389/fcimb.2015.00075

PMCID: PMC4621481 Article PubReader PDF–815KCitation