Cập nhật một số công trình nghiên cứu về sán lá gan lớn kháng thuốc triclabendazole trên thế giới và Việt Nam

Understanding triclabendazole resistance.

Brennan GP, Fairweather I, Trudgett A, Hoey E, McCoy, McConville M, Meaney M, Robinson M, McFerran N, Ryan L, Lanusse C, Mottier L, Alvarez L, Solana H, Virkel G, Brophy PM.

Exp Mol Pathol. 2007 Apr;82(2):104‐9. Epub 2007 Feb 15. Review.

PMID: 17398281

Current Threat of Triclabendazole Resistance in Fasciola hepatica.

Kelley JM, Elliott TP, Beddoe T, Anderson G, Skuce P, Spithill TW.

Trends Parasitol. 2016 Jun;32(6):458‐469. doi: 10.1016/j.pt.2016.03.002. Epub 2016 Apr 2. Review.

PMID: 27049013

Triclabendazole progress report, 2005-2009: an advancement of learning?

Fairweather I.

J Helminthol. 2009 Jun;83(2):139‐50. doi: 10.1017/S0022149X09321173. Epub 2009 Apr 15. Review.

PMID: 19366485

Fasciola hepatica: a comparative survey of adult fluke resistance to triclabendazole, nitroxynil and closantel o­n selected upland and lowland sheep farms in Northern Ireland using faecal egg counting, coproantigen ELISA testing and fluke histology.

Hanna RE, McMahon C, Ellison S, Edgar HW, Kajugu PE, Gordon A, Irwin D, Barley JP, Malone FE, Brennan GP, Fairweather I.

Vet Parasitol. 2015 Jan 15;207(1‐2):34‐43. doi: 10.1016/j.vetpar.2014.11.016. Epub 2014 Nov 24.

PMID: 25529143

Hình 1

Reducing the future threat from (liver) fluke: realistic prospect or quixotic fantasy?

Fairweather I.

Vet Parasitol. 2011 Aug 4;180(1‐2):133‐43. doi: 10.1016/j.vetpar.2011.05.034. Epub 2011 May 27. Review.

PMID: 21703766

Triclabendazole: new skills to unravel an old(ish) enigma.

Fairweather I.

J Helminthol. 2005 Sep;79(3):227‐34. Review.

PMID: 16153316

Fasciola hepatica: histological changes in the reproductive structures of triclabendazole (TCBZ)-sensitive and TCBZ-resistant flukes after treatment in vivo with TCBZ and the related benzimidazole derivative, Compound Alpha.

Hanna RE, Edgar HW, McConnell S, Toner E, McConville M, Brennan GP, Devine C, Flanagan A, Halferty L, Meaney M, Shaw L, Moffett D, McCoy M, Fairweather I.

Vet Parasitol. 2010 Mar 25;168(3‐4):240‐54. doi: 10.1016/j.vetpar.2009.11.014. Epub 2009 Nov 27.

PMID: 20053501

The T687G SNP in a P-glycoprotein gene of Fasciola hepatica is not associated with resistance to triclabendazole in two resistant Australian populations.

Elliott TP, Spithill TW.

Mol Biochem Parasitol. 2014 Nov;198(1):45‐7. doi: 10.1016/j.molbiopara.2014.11.006. Epub 2014 Dec 4.

PMID: 25481750

Hình 2

Potentiation of triclabendazole action in vivo against a triclabendazole-resistant isolate of Fasciola hepatica following its co-administration with the metabolic inhibitor, ketoconazole.

Devine C, Brennan GP, Lanusse CE, Alvarez LI, Trudgett A, Hoey E, Fairweather I.

Vet Parasitol. 2012 Feb 28;184(1):37‐47. doi: 10.1016/j.vetpar.2011.08.006. Epub 2011 Aug 6.

PMID: 21872399

Evidence for high genetic diversity of NAD1 and COX1 mitochondrial haplotypes among triclabendazole resistant and susceptible populations and field isolates of Fasciola hepatica (liver fluke) in Australia.

Elliott T, Muller A, Brockwell Y, Murphy N, Grillo V, Toet HM, Anderson G, Sangster N, Spithill TW.

Vet Parasitol. 2014 Feb 24;200(1‐2):90‐6. doi: 10.1016/j.vetpar.2013.11.019. Epub 2013 Dec 1.

PMID: 24360656

Comparative proteomic analysis of triclabendazole response in the liver fluke Fasciola hepatica.

Chemale G, Perally S, LaCourse EJ, Prescott MC, Jones LM, Ward D, Meaney M, Hoey E, Brennan GP, Fairweather I, Trudgett A, Brophy PM.

J Proteome Res. 2010 Oct 1;9(10):4940‐51. doi: 10.1021/pr1000785.

PMID: 20726552

Altered drug influx/efflux and enhanced metabolic activity in triclabendazole-resistant liver flukes.

Alvarez LI, Solana HD, Mottier ML, Virkel GL, Fairweather I, Lanusse CE.

Parasitology. 2005 Oct;131(Pt 4):501‐10.

PMID: 16174415

Resistance of Fasciola hepatica against triclabendazole in cattle and sheep in The netherlands.

Moll L, Gaasenbeek CP, Vellema P, Borgsteede FH.

Vet Parasitol. 2000 Jul 24;91(1‐2):153‐8.

PMID: 10889368

Hình 3

High prevalence of fasciolosis and evaluation of drug efficacy against Fasciola hepatica in dairy cattle in the Maffra and Bairnsdale districts of Gippsland, Victoria, Australia.

Elliott TP, Kelley JM, Rawlin G, Spithill TW.

Vet Parasitol. 2015 Apr 15;209(1‐2):117‐24. doi: 10.1016/j.vetpar.2015.02.014. Epub 2015 Feb 23.

PMID: 25771931

Disruption of vitellogenesis and spermatogenesis by triclabendazole (TCBZ) in a TCBZ-resistant isolate of Fasciola hepatica following incubation in vitro with a P-glycoprotein inhibitor.

Savage J, Meaney M, Brennan GP, Hoey E, Trudgett A, Fairweather I.

Parasitology. 2014 Jul;141(8):1064‐79. doi: 10.1017/S0031182014000377.

PMID: 24889697

Unchanged triclabendazole kinetics after co-administration with ivermectin and methimazole: failure of its therapeutic activity against triclabendazole-resistant liver flukes.

Ceballos L, Moreno L, Alvarez L, Shaw L, Fairweather I, Lanusse C.

BMC Vet Res. 2010 Feb 3;6:8. doi: 10.1186/1746‐6148‐6‐8.

PMID: 20128898 Free PMC Article

Increase of gluthatione S-transferase, carboxyl esterase and carbonyl reductase in Fasciola hepatica recovered from triclabendazole treated sheep.

Scarcella S, Solana MV, Fernandez V, Lamenza P, Ceballos L, Solana H.

Mol Biochem Parasitol. 2013 Oct;191(2):63‐5. doi: 10.1016/j.molbiopara.2013.09.002. Epub 2013 Sep 13.

PMID: 24041589

Inhibition of triclabendazole metabolism in vitro by ketoconazole increases disruption to the tegument of a triclabendazole-resistant isolate of Fasciola hepatica.

Devine C, Brennan GP, Lanusse CE, Alvarez LI, Trudgett A, Hoey E, Fairweather I.

Parasitol Res. 2011 Oct;109(4):981‐95. doi: 10.1007/s00436‐011‐2304‐9. Epub 2011 Mar 26. Corrected and republished in: Parasitol Res. 2011 Oct;109(4):1209-23.

PMID: 21442257

Hình 4

Lack of reversion in triclabendazole-resistant Fasciola hepatica.

Borgsteede FH, Moll L, Vellema P, Gaasenbeek CP.

Vet Rec. 2005 Mar 12;156(11):350‐1. No abstract available.

PMID: 15789649

Evaluation of the comparative efficacy of a moxidectin plus triclabendazole pour-on solution against adult and immature liver fluke, Fasciola hepatica, in cattle.

Geurden T, Bartram D, Van Brussel L, Bo L, Scott‐Baird E, Rugg D.

Vet Parasitol. 2012 Oct 26;189(2‐4):227‐32. doi: 10.1016/j.vetpar.2012.04.019. Epub 2012 Apr 20.

PMID: 22579500 Similar articles

Resistance of Fasciola hepatica against triclabendazole in cattle in Patagonia (Argentina).

Olaechea F, Lovera V, Larroza M, Raffo F, Cabrera R.

Vet Parasitol. 2011 Jun 10;178(3‐4):364‐6. doi: 10.1016/j.vetpar.2010.12.047. Epub 2011 Jan 11.

PMID: 21277090

An evaluation of the efficacy of compound alpha and triclabendazole against two isolates of Fasciola hepatica.

McConville M, Brennan GP, Flanagan A, Edgar HW, Hanna RE, McCoy M, Gordon AW, Castillo R, Hernández‐Campos A, Fairweather I.

Vet Parasitol. 2009 May 26;162(1‐2):75‐88. doi: 10.1016/j.vetpar.2009.02.004. Epub 2009 Feb 12.

PMID: 19282108

Standardisation of a coproantigen reduction test (CRT) protocol for the diagnosis of resistance to triclabendazole in Fasciola hepatica.

Flanagan AM, Edgar HW, Forster F, Gordon A, Hanna RE, McCoy M, Brennan GP, Fairweather I.

Vet Parasitol. 2011 Feb 28;176(1):34‐42. doi: 10.1016/j.vetpar.2010.10.037. Epub 2010 Oct 27.

PMID: 21093156

Fasciola hepatica: histological demonstration of apoptosis in the reproductive organs of flukes of triclabendazole-sensitive and triclabendazole-resistant isolates, and in field-derived flukes from triclabendazole-treated hosts, using in situ hybridisation to visualise endonuclease-generated DNA strand breaks.

Hanna RE, Forster FI, Brennan GP, Fairweather I.

Vet Parasitol. 2013 Jan 31;191(3‐4):240‐51. doi: 10.1016/j.vetpar.2012.09.014. Epub 2012 Sep 18.

PMID: 23062689

Resistance of Fasciola hepatica against Triclabendazole in cattle in Cajamarca (Peru): a clinical trial and an in vivo efficacy test in sheep.

Ortiz P, Scarcella S, Cerna C, Rosales C, Cabrera M, Guzmán M, Lamenza P, Solana H.

Vet Parasitol. 2013 Jul 1;195(1‐2):118‐21. doi: 10.1016/j.vetpar.2013.01.001. Epub 2013 Jan 10.

PMID: 23352107

Hình 5

Activity of closantel against adult triclabendazole-resistant Fasciola hepatica.

Coles GC, Rhodes AC, Stafford KA.

Vet Rec. 2000 Apr 22;146(17):504. No abstract available.

PMID: 10888001

Diagnosis of triclabendazole resistance in Fasciola hepatica.

Sargison N.

Vet Rec. 2012 Aug 11;171(6):151‐2. doi: 10.1136/vr.e5357. No abstract available.

PMID: 22890399

Triclabendazole-resistant liver fluke in Scottish sheep.

Mitchell GB, Maris L, Bonniwell MA.

Vet Rec. 1998 Oct 3;143(14):399. No abstract available.

PMID: 9802201

Triclabendazole-resistant Fasciola hepatica in southwest Wales.

Thomas I, Coles GC, Duffus K.

Vet Rec. 2000 Feb 12;146(7):200. No abstract available.

PMID: 10718597 Similar articles

Fasciola hepatica: ultrastructural effects of a combination of triclabendazole and clorsulon against mature fluke.

Meaney M, Allister J, McKinstry B, McLaughlin K, Brennan GP, Forbes AB, Fairweather I.

Parasitol Res. 2007 Apr;100(5):1091‐104. Epub 2006 Dec 19.

PMID: 17180691

Resistance of Fasciola hepatica to triclabendazole and albendazole in sheep in Spain.

Alvarez‐Sánchez MA, Mainar‐Jaime RC, Pérez‐García J, Rojo‐Vázquez FA.

Vet Rec. 2006 Sep 23;159(13):424‐5. No abstract available.

PMID: 16998003 Similar articles

Albendazole enantiomeric metabolism and binding to cytosolic proteins in the liver fluke Fasciola hepatica.

Solana H, Scarcella S, Virkel G, Ceriani C, Rodríguez J, Lanusse C.

Vet Res Commun. 2009 Feb;33(2):163‐73. doi: 10.1007/s11259‐008‐9166‐3. Epub 2008 Aug 26.

PMID: 18726703 Similar articles

Time-course and accumulation of triclabendazole and its metabolites in bile, liver tissues and flukes collected from treated sheep.

Moreno L, Ceballos L, Fairweather I, Lanusse C, Alvarez L.

Exp Parasitol. 2014 Jan;136:14‐9. doi: 10.1016/j.exppara.2013.10.014. Epub 2013 Nov 7.

PMID: 24211244

Hình 6

In vivo and in vitro sensitivity of Fasciola hepatica to triclabendazole combined with artesunate, artemether, or OZ78.

Duthaler U, Smith TA, Keiser J.

Antimicrob Agents Chemother. 2010 Nov;54(11):4596‐604. doi: 10.1128/AAC.00828‐10. Epub 2010 Aug 23.

PMID: 20733042 Free PMC Article

Apparent triclabendazole-resistant human Fasciola hepatica infection, the Netherlands.

Winkelhagen AJ, Mank T, de Vries PJ, Soetekouw R.

Emerg Infect Dis. 2012 Jun;18(6):1028‐9. doi: 10.3201/eid1806.120302. No abstract available.

PMID: 22607719 Free PMC Article

Liver fluke control o­n sheep farms in Northern Ireland: A survey of changing management practices in relation to disease prevalence and perceived triclabendazole resistance.

McMahon C, Edgar HW, Hanna RE, Ellison SE, Flanagan AM, McCoy M, Kajugu PE, Gordon AW, Irwin D, Barley JE, Malone FE, Brennan GP, Fairweather I.

Vet Parasitol. 2016 Jan 30;216:72‐83. doi: 10.1016/j.vetpar.2015.11.018. Epub 2015 Dec 12.

PMID: 26801598 Similar articles

Anthelmintic efficacy of triclabendazole against Fasciola hepatica in sheep.

Turner K, Armour J, Richards RJ.

Vet Rec. 1984 Jan 14;114(2):41‐2. No abstract available.

PMID: 6719804 Similar articles

Identification of putative markers of triclabendazole resistance by a genome-wide analysis of genetically recombinant Fasciola hepatica.

Hodgkinson J, Cwiklinski K, Beesley NJ, Paterson S, Williams DJ.

Parasitology. 2013 Oct;140(12):1523‐33. doi: 10.1017/S0031182013000528. Epub 2013 May 31.

PMID: 23721579 Similar articles

Hình 7

Increased action of triclabendazole (TCBZ) in vitro against a TCBZ-resistant isolate of Fasciola hepatica following its co-incubation with the P-glycoprotein inhibitor, R(+)-verapamil.

Savage J, Meaney M, Brennan GP, Hoey E, Trudgett A, Fairweather I.

Exp Parasitol. 2013 Nov;135(3):642‐53. doi: 10.1016/j.exppara.2013.09.015. Epub 2013 Oct 1.

PMID: 24090567 Similar articles

Increase of carboxylesterase activity in Fasciola hepatica recovered from triclabendazole treated sheep.

Scarcella S, Miranda‐Miranda E, Cossío‐Bayúgar R, Ceballos L, Fernandez V, Solana H.

Mol Biochem Parasitol. 2012 Oct;185(2):151‐3. doi: 10.1016/j.molbiopara.2012.07.001. Epub 2012 Jul 16.

PMID: 22814337 Similar articles

A single amino acid substitution in isozyme GST mu in Triclabendazole resistant Fasciola hepatica (Sligo strain) can substantially influence the manifestation of anthelmintic resistance.

Fernández V, Estein S, Ortiz P, Luchessi P, Solana V, Solana H.

Exp Parasitol. 2015 Dec;159:274‐9. doi: 10.1016/j.exppara.2015.10.007. Epub 2015 Nov 2.

PMID: 26542261 Similar articles

Resistance-induced changes in triclabendazole transport in Fasciola hepatica: ivermectin reversal effect.

Mottier L, Alvarez L, Fairweather I, Lanusse C.

J Parasitol. 2006 Dec;92(6):1355‐60.

PMID: 17304820 Similar articles

Raising the bar o­n reporting ‘triclabendazole resistance’.

Fairweather I.

Vet Rec. 2011 May 14;168(19):514‐5. doi: 10.1136/vr.d2867. No abstract available.

PMID: 21571852 Similar articles

In vitro effects of triclabendazole (TCBZ) o­n the excretory-secretory products (ESP) of Fasciola spp parasites.

Farahnak A, Golmohamdi T, Eshraghian M.

Acta Med Iran. 2012;50(3):164‐8.

PMID: 22418984 Free Article

Efficacy of an anthelmintic combination in sheep infected with Fasciola hepatica resistant to albendazole and clorsulon.

Martínez‐Valladares M, Cordero‐Pérez C, Rojo‐Vázquez FA.

Exp Parasitol. 2014 Jan;136:59‐62. doi: 10.1016/j.exppara.2013.10.010. Epub 2013 Nov 6.

PMID: 24211419 Similar articles

Effect of the P-glycoprotein inhibitor, R(+)-verapamil o­n the drug susceptibility of a triclabendazole-resistant isolate of Fasciola hepatica.

Savage J, Meaney M, Brennan GP, Hoey E, Trudgett A, Fairweather I.

Vet Parasitol. 2013 Jul 1;195(1‐2):72‐86. doi: 10.1016/j.vetpar.2013.03.007. Epub 2013 Mar 22.

PMID: 23597772 Similar articles

Anthelmintic resistance: potential benefits of ‘over-diagnosis’.

Sargison ND, Scott PR.

Vet Rec. 2011 Jun 18;168(24):646‐7. doi: 10.1136/vr.d3740. No abstract available.

PMID: 21685422 Similar articles

The field evaluation of albendazole and triclabendazole efficacy against Fasciola hepatica by coproantigen ELISA in naturally infected sheep.

Novobilský A, Averpil HB, Höglund J.

Vet Parasitol. 2012 Nov 23;190(1‐2):272‐6. doi: 10.1016/j.vetpar.2012.06.022. Epub 2012 Jun 26.

PMID: 22818198 Similar articles

Hình 8

Fasciolicides: efficacy, actions, resistance and its management.

Fairweather I, Boray JC.

Vet J. 1999 Sep;158(2):81‐112. Review.

PMID: 10489266 Similar articles

Composite faecal egg count reduction test to detect resistance to triclabendazole in Fasciola hepatica.

Daniel R, van Dijk J, Jenkins T, Akca A, Mearns R, Williams DJ.

Vet Rec. 2012 Aug 11;171(6):153, 1‐5. doi: 10.1136/vr.100588. Epub 2012 Jul 11.

PMID: 22791519 Similar articles

Resistance of Fasciola hepatica to triclabendazole.

Overend DJ, Bowen FL.

Aust Vet J. 1995 Jul;72(7):275‐6. No abstract available.

PMID: 8534235 Similar articles

Efficacy of nitroxynil against Fasciola hepatica resistant to triclabendazole in a naturally infected sheep flock.

Martínez‐Valladares M, del Rosario Famularo M, Fernández‐Pato N, Castañón‐Ordóñez L, Cordero‐Pérez C, Rojo‐Vázquez FA.

Parasitol Res. 2010 Oct;107(5):1205‐11. doi: 10.1007/s00436‐010‐1989‐5. Epub 2010 Aug 3.

PMID: 20680341 Similar articles

The efficacy of triclabendazole (Fasinex) against immature and adult Fasciola hepatica in experimentally infected cattle.

Shi FH, Lin BF, Qian CG, Li M, Fang MB, Ma JL, Shen W, Wang SW, Jian XL.

Vet Parasitol. 1989 Sep;33(2):117‐24.

PMID: 2800300 Similar articles

Diagnosis of resistance to triclabendazole.

Jones EM, Daniel R, Coles GC.

Vet Rec. 2014 May 31;174(22):560. doi: 10.1136/vr.g3566. No abstract available.

PMID: 24920715 Similar articles

Tegumental surface changes in juvenile Fasciola hepatica in response to treatment in vivo with triclabendazole.

Halferty L, Brennan GP, Hanna RE, Edgar HW, Meaney MM, McConville M, Trudgett A, Hoey L, Fairweather I.

Vet Parasitol. 2008 Aug 1;155(1‐2):49‐58. doi: 10.1016/j.vetpar.2008.04.011. Epub 2008 Apr 22.

PMID: 18511199 Similar articles

Hình 9

Efficacy of triclabendazole against Fasciola hepatica in sheep and goats.

Wolff K, Eckert J, Schneiter G, Lutz H.

Vet Parasitol. 1983 Sep;13(2):145‐50.

PMID: 6685399 Similar articles

Increased susceptibility of a triclabendazole (TCBZ)-resistant isolate of Fasciola hepatica to TCBZ following co-incubation in vitro with the P-glycoprotein inhibitor, R(+)-verapamil.

Meaney M, Savage J, Brennan GP, Hoey E, Trudgett A, Fairweather I.

Parasitology. 2013 Sep;140(10):1287‐303. doi: 10.1017/S0031182013000759. Epub 2013 Jun 12.

PMID: 23756576 Similar articles

Potentiation of triclabendazole sulphoxide-induced tegumental disruption by methimazole in a triclabendazole-resistant isolate of Fasciola hepatica.

Devine C, Brennan GP, Lanusse CE, Alvarez LI, Trudgett A, Hoey E, Fairweather I.

Parasitol Res. 2010 May;106(6):1351‐63. doi: 10.1007/s00436‐010‐1806‐1. Epub 2010 Mar 25.

PMID: 20336319 Similar articles

Piperonyl butoxide enhances triclabendazole action against triclabendazole-resistant Fasciola hepatica.

Devine C, Brennan GP, Lanusse CE, Alvarez LI, Trudgett A, Hoey E, Fairweather I.

Parasitology. 2011 Feb;138(2):224‐36. doi: 10.1017/S0031182010001125. Epub 2010 Oct 15.

PMID: 20946692 Similar articles

Triclabendazole resistance involving Fasciola hepatica in sheep and goats during an outbreak in Almirante Tamandare, Paraná, Brazil.

Oliveira DR, Ferreira DM, Stival CC, Romero F, Cavagnolli F, Kloss A, Araújo FB, Molento MB.

Rev Bras Parasitol Vet. 2008 Sep;17 Suppl 1:149‐53.

PMID: 20059835 Similar articles

A study of a restricted programme of strategic dosing against Fasciola hepatica with triclabendazole.

Fawcett AR.

Vet Rec. 1990 Nov 17;127(20):492‐3.

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Identification of a field isolate of Fasciola hepatica resistant to albendazole and susceptible to triclabendazole.

Sanabria R, Ceballos L, Moreno L, Romero J, Lanusse C, Alvarez L.

Vet Parasitol. 2013 Mar 31;193(1‐3):105‐10. doi: 10.1016/j.vetpar.2012.11.033. Epub 2012 Dec 5.

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Efficacy against Fasciola hepatica and the pharmacokinetics of triclabendazole administered by oral and topical routes.

Martin P, Chambers M, Hennessy D.

Aust Vet J. 2009 May;87(5):200‐3. doi: 10.1111/j.1751‐0813.2009.00425.x.

PMID: 19382929 Similar articles

Comparative assessment of albendazole and triclabendazole ovicidal activity o­n Fasciola hepatica eggs.

Alvarez L, Moreno G, Moreno L, Ceballos L, Shaw L, Fairweather I, Lanusse C.

Vet Parasitol. 2009 Oct 14;164(2‐4):211‐6. doi: 10.1016/j.vetpar.2009.05.014. Epub 2009 May 20.

PMID: 19560276 Similar articles

Enhancement of triclabendazole action in vivo against a triclabendazole-resistant isolate of Fasciola hepatica by co-treatment with ketoconazole.

Devine C, Brennan GP, Lanusse CE, Alvarez LI, Trudgett A, Hoey E, Fairweather I.

Vet Parasitol. 2011 May 11;177(3‐4):305‐15. doi: 10.1016/j.vetpar.2010.12.002. Epub 2010 Dec 13.

PMID: 21208747 Similar articles

Tegumental surface changes in adult Fasciola hepatica in response to treatment in vivo with triclabendazole in the sheep host.

Toner E, Brennan GP, Hanna RE, Edgar HW, Fairweather I.

Vet Parasitol. 2010 Sep 20;172(3‐4):238‐48. doi: 10.1016/j.vetpar.2010.05.012. Epub 2010 May 16.

PMID: 20627418 Similar articles

The efficacy of formulations of triclabendazole and ivermectin in combination against liver fluke (Fasciola hepatica) and gastro-intestinal nematodes in cattle and sheep and sucking lice species in cattle.

Stevenson CR, Mahoney RH, Fisara P, Strehlau G, Reichel MP.

Aust Vet J. 2002 Nov;80(11):698‐701.

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Experiments o­n anthelmintic control of Fasciola hepatica in Brazil.

Echevarria FA, Correa MB, Wehrle RD, Correa IF.

Vet Parasitol. 1992 Jul;43(3‐4):211‐22.

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On farm evaluation of the coproantigen ELISA and coproantigen reduction test in Scottish sheep naturally infected with Fasciola hepatica.

Gordon DK, Zadoks RN, Stevenson H, Sargison ND, Skuce PJ.

Vet Parasitol. 2012 Jul 6;187(3‐4):436‐44. doi: 10.1016/j.vetpar.2012.02.009. Epub 2012 Feb 21.

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Diagnosis and economic consequences of triclabendazole resistance in Fasciola hepatica in a sheep flock in south-east Scotland.

Sargison ND, Scott PR.

Vet Rec. 2011 Feb 12;168(6):159. doi: 10.1136/vr.c5332. Epub 2011 Feb 1.

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Early o­nset of changes to the reproductive system of Fasciola hepatica following in vivo treatment with triclabendazole.

Hanna RE, Scarcella S, Solana H, McConnell S, Fairweather I.

Vet Parasitol. 2012 Mar 23;184(2‐4):341‐7. doi: 10.1016/j.vetpar.2011.08.023. Epub 2011 Aug 19.

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Time-dependent changes to the tegumental system and gastrodermis of adult Fasciola hepatica following treatment in vivo with triclabendazole in the sheep host.

Toner E, Brennan GP, Hanna RE, Edgar HW, Fairweather I.

Vet Parasitol. 2010 Dec 15;174(3‐4):218‐27. doi: 10.1016/j.vetpar.2010.09.008. Epub 2010 Sep 16.

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Comparative kinetics of serological and coproantigen ELISA and faecal egg count in cattle experimentally infected with Fasciola hepatica and following treatment with TCBZ.

Brockwell YM, Spithill TW, Anderson GR, Grillo V, Sangster NC.

Vet Parasitol. 2013 Sep 23;196(3‐4):417‐26. doi: 10.1016/j.vetpar.2013.04.012. Epub 2013 Apr 16.

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Relative activity of triclabendazole metabolites against the liver fluke, Fasciola hepatica.

Halferty L, Brennan GP, Trudgett A, Hoey L, Fairweather I.

Vet Parasitol. 2009 Feb 5;159(2):126‐38. doi: 10.1016/j.vetpar.2008.10.007. Epub 2008 Oct 11.

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Field trials of triclabendazole against mixed age infections of Fasciola hepatica in sheep and cattle.

Stansfield DG, Lonsdale B, Lowndes PA, Reeves EW, Schofield DM.

Vet Rec. 1987 May 9;120(19):459‐60. No abstract available.

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Adult triclabendazole-resistant Fasciola hepatica: surface and subsurface tegumental responses to in vitro treatment with the sulphoxide metabolite of the experimental fasciolicide compound alpha.

McConville M, Brennan GP, McCoy M, Castillo R, Hernandez‐Campos A, Ibarra F, Fairweather I.

Parasitology. 2006 Aug;133(Pt 2):195‐208. Epub 2006 May 2.

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Comparative assessment of the access of albendazole, fenbendazole and triclabendazole to Fasciola hepatica: effect of bile in the incubation medium.

Alvarez LI, Mottier ML, Lanusse CE.

Parasitology. 2004 Jan;128(Pt 1):73‐81.

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A transmission electron microscope study o­n the route of entry of triclabendazole into the liver fluke, Fasciola hepatica.

Toner E, Brennan GP, McConvery F, Meaney M, Fairweather I.

Parasitology. 2010 Apr;137(5):855‐70. doi: 10.1017/S0031182009991247. Epub 2009 Dec 24.

PMID: 20030907 Similar articles

Characterisation of a beta-tubulin gene from the liver fluke, Fasciola hepatica.

Robinson MW, Hoey EM, Fairweather I, Dalton JP, McGonigle S, Trudgett A.

Int J Parasitol. 2001 Sep;31(11):1264‐8.

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