Cập nhật các nghiên cứu chuyên sâu về sốt rét đăng tải trên các tạp chí quốc tế nổi tiếng năm 2016‐2017

Novel lead structures with both Plasmodium falciparum gametocytocidal and asexual blood stage activity identified from high throughput compound screening

Blocking malaria transmission is an important step in eradicating malaria. In the field, transmission requires the production of sexual stage Plasmodium parasites, called gametocytes, which are not effectively ki…

Wei Sun, Xiuli Huang, Hao Li, Gregory Tawa, Ethan Fisher, Takeshi Q. Tanaka, Paul Shinn, Wenwei Huang, Kim C. Williamson and Wei Zheng

Malaria Journal 2017 16:147

Patterns of inflammatory responses and parasite tolerance vary with malaria transmission intensity

In individuals living in malaria‐endemic regions, parasitaemia thresholds for the o­nset of clinical symptoms vary with transmission intensity. The mechanisms that mediate this relationship are however, unclear…

Temitope W. Ademolue, Yaw Aniweh, Kwadwo A. Kusi and Gordon A. Awandare

Malaria Journal 2017 16:145

Caregivers’ perception of malaria and treatment-seeking behaviour for under five children in Mandura District, West Ethiopia: a cross-sectional study

Early diagnosis and prompt malaria treatment is essential to reduce progression of the illness to severe disease and, therefore, decrease mortality particularly among children under 5 years of age. This study …

Israel Mitiku and Adane Assefa

Malaria Journal 2017 16:144

Challenges for achieving safe and effective radical cure of Plasmodium vivax: a round table discussion of the APMEN Vivax Working Group

The delivery of safe and effective radical cure for Plasmodium vivax is o­ne of the greatest challenges for achieving malaria elimination from the Asia‐Pacific by 2030. During the annual meeting of the Asia Pacifi…

Kamala Thriemer, Benedikt Ley, Albino Bobogare, Lek Dysoley, Mohammad Shafiul Alam, Ayodhia P. Pasaribu, Jetsumon Sattabongkot, Elodie Jambert, Gonzalo J. Domingo, Robert Commons, Sarah Auburn, Jutta Marfurt, Angela Devine, Mohammad M. Aktaruzzaman, Nayeem Sohel, Rinzin Namgay…

Malaria Journal 2017 16:141

Characterization of Plasmodium falciparum genes associated with drug resistance in Hodh Elgharbi, a malaria hotspot near Malian–Mauritanian border

A malaria hotspot in the southeastern region of Mauritania, near the Malian border, may hamper malaria control strategies. The objectives were to estimate the prevalence of genetic polymorphisms associated wit…

Mohamed Salem Ould Ahmedou Salem, Khadijetou Mint Lekweiry, Houssem Bouchiba, Aurelie Pascual, Bruno Pradines, Ali Ould Mohamed Salem Boukhary, Sébastien Briolant, Leonardo K. Basco and Hervé Bogreau

Malaria Journal 2017 16:140

A novel model fitted to multiple life stages of malaria for assessing efficacy of transmission-blocking interventions

Transmission‐blocking interventions (TBIs) aim to eliminate malaria by reducing transmission of the parasite between the host and the invertebrate vector. TBIs include transmission‐blocking drugs and vaccines …

Ellie Sherrard‐Smith, Thomas S. Churcher, Leanna M. Upton, Katarzyna A. Sala, Sara E. Zakutansky, Hannah C. Slater, Andrew M. Blagborough and Michael Betancourt

Malaria Journal 2017 16:137

Genotypic and phenotypic characterization of G6PD deficiency in Bengali adults with severe and uncomplicated malaria

Control of malaria increasingly involves administration of 8‐aminoquinolines, with accompanying risk of haemolysis in individuals with glucose‐6‐phosphate dehydrogenase (G6PD) deficiency. Few data o­n the preva…

Katherine Plewes, Ingfar Soontarawirat, Aniruddha Ghose, Germana Bancone, Hugh W. F. Kingston, M. Trent Herdman, Stije J. Leopold, Haruhiko Ishioka, Md. Abul Faiz, Nicholas M. Anstey, Nicholas P. J. Day, Md. Amir Hossain, Mallika Imwong, Arjen M. Dondorp and Charles J. Woodrow

Malaria Journal 2017 16:134

Identification of a novel merozoite surface antigen of Plasmodium vivax, PvMSA180

Although a number of Plasmodium vivax proteins have been identified, few have been investigated as potential vaccine candidates. This study characterized the Plasmodium vivax merozoite surface antigen 180 (PvMSA1…

Fauzi Muh, Jin‐Hee Han, Myat Htut Nyunt, Seong‐Kyun Lee, Hye‐Yoon Jeon, Kwon‐Soo Ha, Won Sun Park, Seok‐Ho Hong, Md Atique Ahmed, Sunghun Na, Eizo Takashima, Takafumi Tsuboi and Eun‐Taek Han

Malaria Journal 2017 16:133

A novel in vitro model reveals distinctive modulatory roles of Plasmodium falciparum and Plasmodium vivax o­n naïve cell-mediated immunity

To date, human peripheral blood mononuclear cells (PBMCs) have been used mainly in immune stimulation assays and the interpretation of data can be influenced by the previous immunological history of donors and…

Setthakit Chitsanoor, Sangdao Somsri, Panyu Panburana, Mathirut Mungthin, Ratawan Ubalee, Maliwan Emyeam, Somchai Jongwutiwes, Jetsumon Sattabongkot and Rachanee Udomsangpetch

Malaria Journal 2017 16:131

Predictors of the use of interventions to prevent malaria in pregnancy in Cameroon

Malaria in pregnancy is common in sub‐Saharan Africa where it contributes to perinatal morbidity and mortality. Use of insecticide‐treated bed nets and intermittent preventive therapy with sulfadoxine‐pyrimeth…

Jodie Dionne‐Odom, Andrew O. Westfall, Tobias O. Apinjoh, Judith Anchang‐Kimbi, Eric A. Achidi and Alan T. N. Tita

Malaria Journal 2017 16:132

Analytical sensitivity of current best-in-class malaria rapid diagnostic tests

Rapid diagnostic tests (RDTs) are today the most widely used method for malaria diagnosis and are recommended, alongside microscopy, for the confirmation of suspected cases before the administration of anti‐ma…

Alfons Jimenez, Roxanne R. Rees‐Channer, Rushini Perera, Dionicia Gamboa, Peter L. Chiodini, Iveth J. González, Alfredo Mayor and Xavier C. Ding

Malaria Journal 2017 16:128

Diagnostic challenges and case management of the first imported case of Plasmodium knowlesi in Sri Lanka

Sri Lanka has achieved ‘malaria‐free’ status and is now in the phase of prevention of re‐introduction of malaria. Imported malaria remains a challenge to resurgence of the disease. The diagnostic challenges en…

A. Dewanee Ranaweera, Manjula N. Danansuriya, Kusumawathie Pahalagedera, W. M. Kumudunayana T. de A. W. Gunasekera, Priyani Dharmawardena, Keng Wai Mak, Pei‐Sze Jeslyn Wong, Mei‐Zhi Irene Li, Cheong Huat Tan, Hapuarachchige C. Hapuarachchi, Hema D. B. Herath and Deepika Fernando

Malaria Journal 2017 16:126

An assessment of national surveillance systems for malaria elimination in the Asia Pacific

Heads of Government from Asia and the Pacific have committed to a malaria‐free region by 2030. In 2015, the total number of confirmed cases reported to the World Health Organization by 22 Asia Pacific countrie…

Chris Erwin G. Mercado, Nattwut Ekapirat, Arjen M. Dondorp and Richard J. Maude

Malaria Journal 2017 16:127

Drug resistance mediating Plasmodium falciparum polymorphisms and clinical presentations of parasitaemic children in Uganda

Plasmodium falciparum genetic polymorphisms that mediate altered drug sensitivity may impact upon virulence. In a cross‐sectional study, Ugandan children with infections mutant at pfcr…

Stephen Tukwasibwe, Patrick Tumwebaze, Melissa Conrad, Emmanuel Arinaitwe, Moses R. Kamya, Grant Dorsey, Samuel L. Nsobya, Bryan Greenhouse and Philip J. Rosenthal

Malaria Journal 2017 16:125

El Niño Southern Oscillation as an early warning tool for malaria outbreaks in India

Risks of malaria epidemics in relation to El Niño and Southern Oscillation (ENSO) events have been mapped and studied at global level. In India, where malaria is a major public health problem, no such effort h…

Ramesh C. Dhiman and Soma Sarkar

Malaria Journal 2017 16:122

False-negative malaria rapid diagnostic tests in Rwanda: impact of Plasmodium falciparum isolates lacking hrp2 and declining malaria transmission

Rapid diagnostic tests (RDTs) for histidine rich protein 2 (HRP2) are often used to determine whether persons with fever should be treated with anti‐malarials. However, Plasmodium falciparum parasites with a dele…

Christina T. Kozycki, Noella Umulisa, Stephen Rulisa, Emil I. Mwikarago, Jean Pierre Musabyimana, Jean Pierre Habimana, Corine Karema and Donald J. Krogstad

Malaria Journal 2017 16:123

Age and geographic patterns of Plasmodium falciparum malaria infection in a representative sample of children living in Burkitt lymphoma-endemic areas of northern Uganda

Falciparum malaria is an important risk factor for African Burkitt lymphoma (BL), but few studies have evaluated malaria patterns in healthy BL‐age children in populations where both diseases are endemic. To o…

Marlena Maziarz, Tobias Kinyera, Isaac Otim, Paul Kagwa, Hadijah Nabalende, Ismail D. Legason, Martin D. Ogwang, Samuel Kirimunda, Benjamin Emmanuel, Steven J. Reynolds, Patrick Kerchan, Moses M. Joloba, Andrew W. Bergen, Kishor Bhatia, Ambrose O. Talisuna, Robert J. Biggar…

Malaria Journal 2017 16:124

Tryptophan-rich domains of Plasmodium falciparum SURFIN_4.2 and Plasmodium vivax PvSTP2 interact with membrane skeleton of red blood cell

Plasmodium falciparum dramatically alters the morphology and properties of the infected red blood cells (iRBCs). A large group of exported proteins participate in these parasite‐host i…

Xiaotong Zhu, Yang He, Yifan Liang, Osamu Kaneko, Liwang Cui and Yaming Cao

Malaria Journal 2017 16:121

Erratum to: Pre‐travel malaria chemoprophylaxis counselling in a public travel medicine clinic in São Paulo, Brazil

Tânia do Socorro Souza Chaves, Wuelton Marcelo Monteiro, Jessé Reis Alves, Marcus Lacerda and Marta Heloisa Lopes

Malaria Journal 2017 16:120

Clinical and molecular surveillance of drug resistant vivax malaria in Myanmar (2009–2016)

One of the major challenges for control and elimination of malaria is o­ngoing spread and emergence of drug resistance. While epidemiology and surveillance of the drug resistance in falciparum malaria is being …

Myat Htut Nyunt, Jin‐Hee Han, Bo Wang, Khin Myo Aye, Kyin Hla Aye, Seong‐Kyun Lee, Ye Htut, Myat Phone Kyaw, Kay Thwe Han and Eun‐Taek Han

Malaria Journal 2017 16:117

Confirmation of Plasmodium falciparum in vitro resistance to monodesethylamodiaquine and chloroquine in Dakar, Senegal, in 2015

In response to increasing resistance to anti‐malarial drugs, Senegal adopted artemisinin‐based combination therapy (ACT) as the first‐line treatment for uncomplicated malaria in 2006. However, resistance of Plasm…

Silman Diawara, Marylin Madamet, Mame Bou Kounta, Gora Lo, Khalifa Ababacar Wade, Aminata Nakoulima, Raymond Bercion, Rémy Amalvict, Mamadou Wague Gueye, Bécaye Fall, Bakary Diatta and Bruno Pradines

Malaria Journal 2017 16:118

Comparison of the diagnostic performance of microscopic examination with nested polymerase chain reaction for optimum malaria diagnosis in Upper Myanmar

Accurate diagnosis of Plasmodium infection is crucial for prompt malaria treatment and surveillance. Microscopic examination has been widely applied as the gold standard for malaria diagnosis in most part of mala…

Jung‐Mi Kang, Pyo‐Yun Cho, Mya Moe, Jinyoung Lee, Hojong Jun, Hyeong‐Woo Lee, Seong Kyu Ahn, Tae Im Kim, Jhang Ho Pak, Moe Kyaw Myint, Khin Lin, Tong‐Soo Kim and Byoung‐Kuk Na

Malaria Journal 2017 16:119

Unexpected selections of Plasmodium falciparum polymorphisms in previously treatment-naïve areas after monthly presumptive administration of three different anti-malarial drugs in Liberia 1976–78

To assess the effect o­n malaria prevalence, village specific monthly administrations of pyrimethamine, chlorproguanil, chloroquine or placebo were given to children in four previously treatment‐naïve Liberian …

Irina T. Jovel, Anders Björkman, Cally Roper, Andreas Mårtensson and Johan Ursing

Malaria Journal 2017 16:113

TOLLIP gene variant is associated with Plasmodium vivax malaria in the Brazilian Amazon

Toll‐interacting protein is a negative regulator in the TLR signaling cascade, particularly by impeding the TLR2 and, TLR4 pathway. Recently, TOLLIP was shown to regulate human TLR signaling pathways. Two common

Larissa W. Brasil, Laila R. A. Barbosa, Felipe J. de Araujo, Allyson G. da Costa, Luan D. O. da Silva, Suzana K. Pinheiro, Anne C. G. de Almeida, Andrea Kuhn, Sheila Vitor‐Silva, Gisely C. de Melo, Wuelton M. Monteiro, Marcus V. G. de Lacerda and Rajendranath Ramasawmy

Malaria Journal 2017 16:116

Rhesus macaque and mouse models for down-selecting circumsporozoite protein based malaria vaccines differ significantly in immunogenicity and functional outcomes

Non‐human primates, such as the rhesus macaques, are the preferred model for down‐selecting human malaria vaccine formulations, but the rhesus model is expensive and does not allow for direct efficacy testing …

Timothy W. Phares, Anthony D. May, Christopher J. Genito, Nathan A. Hoyt, Farhat A. Khan, Michael D. Porter, Margot DeBot, Norman C. Waters, Philippe Saudan and Sheetij Dutta

Malaria Journal 2017 16:115

Combining indoor and outdoor methods for controlling malaria vectors: an ecological model of endectocide-treated livestock and insecticidal bed nets

Malaria is spread by mosquitoes that are increasingly recognised to have diverse biting behaviours. How a mosquito in a specific environment responds to differing availability of blood‐host species is largely …

Laith Yakob, Mary Cameron and Jo Lines

Malaria Journal 2017 16:114

A systematic review of the clinical presentation, treatment and relapse characteristics of human Plasmodium ovale malaria

Despite increased efforts to control and ultimately eradicate human malaria, Plasmodium ovale malaria is for the most part outside the focus of research or public health programmes. Importantly, the understanding…

Mirjam Groger, Hannah S. Fischer, Luzia Veletzky, Albert Lalremruata and Michael Ramharter

Malaria Journal 2017 16:112

Resting and feeding preferences of Anopheles stephensi in an urban setting, perennial for malaria

The Indian city of Chennai is endemic for malaria and the known local malaria vector is Anopheles stephensi. Plasmodium vivax is the predominant malaria parasite species, though Plasmodium falciparum is present a…

Shalu Thomas, Sangamithra Ravishankaran, N. A. Johnson Amala Justin, Aswin Asokan, Manu Thomas Mathai, Neena Valecha, Jacqui Montgomery, Matthew B. Thomas and Alex Eapen

Malaria Journal 2017 16:111

Burden of malaria in mobile populations in the Greater Accra region, Ghana: a cross- sectional study

The burden of malaria in mobile populations remains poorly documented in sub‐Saharan Africa. This study determined the prevalence of malaria among hawkers and long‐distance truck drivers in the Greater Accra r…

Nouhoum Diallo, Patricia Akweongo, Ernest Maya, Moses Aikins and Bismark Sarfo

Malaria Journal 2017 16:109

Prevalence and determinants of malaria among children in Zambézia Province, Mozambique

Malaria is the leading cause of death among children in Mozambique. Prevalence and factors associated with malaria are not well studied among children in rural Zambézia Province. Whether prevalence of malaria …

James G. Carlucci, Meridith Blevins Peratikos, Charlotte B. Cherry, Melanie L. Lopez, Ann F. Green, Lazaro González‐Calvo and Troy D. Moon

Malaria Journal 2017 16:108

Primaquine-thiazolidinones block malaria transmission and development of the liver exoerythrocytic forms

Primaquine is an anti‐malarial used to prevent Plasmodium vivax relapses and malaria transmission. However, PQ metabolites cause haemolysis in patients deficient in the enzyme glucose‐6‐phosphate dehydrogenase (G…

Anna Caroline C. Aguiar, Flávio Jr. B. Figueiredo, Patrícia D. Neuenfeldt, Tony H. Katsuragawa, Bruna B. Drawanz, Wilson Cunico, Photini Sinnis, Fidel Zavala and Antoniana U. Krettli

Malaria Journal 2017 16:110

Preliminary survey o­n Anopheles species distribution in Botswana shows the presence of Anopheles gambiae and Anopheles funestus complexes

Botswana is o­ne of the four front line malaria elimination countries in Southern Africa, with malaria control activities that include routine vector control. Past and recent studies have shown that Anopheles arab…

Leabaneng Tawe, Pleasure Ramatlho, Kelebogile Waniwa, Charles W. Muthoga, Ntebaleng Makate, Davis S. Ntebela, Isaac K. Quaye, Marco Pombi and Giacomo Maria Paganotti

Malaria Journal 2017 16:106

A systematic review o­n malaria sero-epidemiology studies in the Brazilian Amazon: insights into immunological markers for exposure and protection

Considerable success in reducing malaria incidence and mortality has been achieved in Brazil, leading to discussions over the possibility of moving towards elimination. However, more than reporting and countin…

Pedro M. Folegatti, André M. Siqueira, Wuelton M. Monteiro, Marcus Vinícius G. Lacerda, Chris J. Drakeley and Érika M. Braga

Malaria Journal 2017 16:107

Rapid diagnostic tests failing to detect Plasmodium falciparum infections in Eritrea: an investigation of reported false negative RDT results

Relatively large number of false‐negative malaria rapid diagnostic test (RDT) results for microscopically confirmed Plasmodium falciparum cases were reported from five of the six administrative regions of Eritrea…

Araia Berhane, Mulugeta Russom, Iyassu Bahta, Filmon Hagos, Michael Ghirmai and Selam Uqubay

Malaria Journal 2017 16:105

Passive case detection of malaria in Ratanakiri Province (Cambodia) to detect villages at higher risk for malaria

Cambodia reduced malaria incidence by more than 75% between 2000 and 2015, a target of the Millennium Development Goal 6. The Cambodian Government aims to eliminate all forms of malaria by 2025. The country’s …

Somony Heng, Lies Durnez, Sokny Mao, Sovannaroth Siv, Sochantha Tho, Vanna Mean, Vincent Sluydts and Marc Coosemans

Malaria Journal 2017 16:104

Should chemoprophylaxis be a main strategy for preventing re-introduction of malaria in highly receptive areas? Sri Lanka a case in point

Imported malaria cases continue to be reported in Sri Lanka, which was declared ‘malaria‐free’ by the World Health Organization in September 2016. Chemoprophylaxis, a recommended strategy for malaria preventio…

A. Rajitha Wickremasinghe, Renu Wickremasinghe, Hemantha D. B. Herath and S. Deepika Fernando

Malaria Journal 2017 16:102

In vivo efficacy of top five surveyed Ghanaian herbal anti-malarial products

Anti‐malarial herbal preparations (HPs) continue to enjoy high patronage in Ghana despite reports that the artemisinin‐based combination therapy (ACT), the recommended first choice for treatment of uncomplicat…

Dennis Wilmot, Elvis Ofori Ameyaw, Daniel Amoako‐Sakyi, Johnson Nyarko Boampong and Neils Ben Quashie

Malaria Journal 2017 16:103

Evidence of metabolic mechanisms playing a role in multiple insecticides resistance in Anopheles stephensi populations from Afghanistan

Malaria is endemic in most parts of Afghanistan and insecticide‐based vector control measures are central in controlling the disease. Insecticide resistance in the main malaria vector Anopheles stephensi from Afg…

Noor Halim Zahid Safi, Abdul Ali Ahmadi, Sami Nahzat, Seyyed Payman Ziapour, Seyed Hassan Nikookar, Mahmoud Fazeli‐Dinan, Ahmadali Enayati and Janet Hemingway

Malaria Journal 2017 16:100

Exo-erythrocytic development of avian malaria and related haemosporidian parasites

Avian malaria parasites (Plasmodium spp.) and related haemosporidians (Haemosporida) are responsible for diseases which can be severe and even lethal in avian hosts. These parasites cause not o­nly blood pathology…

Gediminas Valkiūnas and Tatjana A. Iezhova

Malaria Journal 2017 16:101

The shape of the iceberg: quantification of submicroscopic Plasmodium falciparum and Plasmodium vivax parasitaemia and gametocytaemia in five low endemic settings in Ethiopia

The widespread presence of low‐density asymptomatic infections with concurrent gametocytes may be a stumbling block for malaria elimination. This study investigated the asymptomatic reservoir of Plasmodium falcip…

Fitsum G. Tadesse, Lotus van den Hoogen, Kjerstin Lanke, Jodie Schildkraut, Kevin Tetteh, Abraham Aseffa, Hassen Mamo, Robert Sauerwein, Ingrid Felger, Chris Drakeley, Endalamaw Gadissa and Teun Bousema

Malaria Journal 2017 16:99

Selections, frameshift mutations, and copy number variation detected o­n the surf _4.1 gene in the western Kenyan Plasmodium falciparum population

Plasmodium falciparum SURFIN_4.1 is a putative ligand expressed o­n the merozoite and likely o­n the infected red blood cell, whose gene was suggested to be under directional selection in…

Jesse N. Gitaka, Mika Takeda, Masatsugu Kimura, Zulkarnain Md Idris, Chim W. Chan, James Kongere, Kazuhide Yahata, Francis W. Muregi, Yoshio Ichinose, Akira Kaneko and Osamu Kaneko

Malaria Journal 2017 16:98

Molecular surveillance of artemisinin resistance falciparum malaria among migrant goldmine workers in Myanmar

Artemisinin resistance has been reported in Greater Mekong Sub‐region countries, including Myanmar. After discovery of artemisinin resistance marker (K13), molecular surveillance o­n artemisinin resistance in e…

Myat Htut Nyunt, Bo Wang, Khin Myo Aye, Kyin Hla Aye, Jin‐Hee Han, Seong‐Kyun Lee, Kay Thwe Han, Ye Htut and Eun‐Taek Han

Malaria Journal 2017 16:97

Assessment of the utility of a symptom-based algorithm for identifying febrile patients for malaria diagnostic testing in Senegal

Malaria rapid diagnostic tests (RDTs) enable point‐of‐care testing to be nearly as sensitive and specific as reference microscopy. The Senegal National Malaria Control Programme introduced RDTs in 2007, along …

Julie Thwing, Fatou Ba, Alou Diaby, Younouss Diedhiou, Assane Sylla, Guelaye Sall, Mame Birame Diouf, Alioune Badara Gueye, Seynabou Gaye, Medoune Ndiop, Moustapha Cisse, Daouda Ndiaye and Mady Ba

Malaria Journal 2017 16:95

Assessing the impact of differences in malaria transmission intensity o­n clinical and haematological indices in children with malaria

Malaria control interventions have led to a decline in transmission intensity in many endemic areas, and resulted in elimination in some areas. This decline, however, will lead to delayed acquisition of protec…

Henrietta E. Mensah‐Brown, James Abugri, Kwaku P. Asante, Duah Dwomoh, David Dosoo, Frank Atuguba, David J. Conway and Gordon A. Awandare

Malaria Journal 2017 16:96

Acceptability of insecticide-treated clothing for malaria prevention among migrant rubber tappers in Myanmar: a cluster-randomized non-inferiority crossover trial

Insecticide‐treated clothing (ITC) has long been used for military and outdoor recreational purposes and there is substantial evidence to show that it can protect against arthropod biting. As a complementary v…

Alison F. Crawshaw, Thae Maung Maung, Muhammad Shafique, Nyan Sint, Sarala Nicholas, Michelle S. Li, Arantxa Roca‐Feltrer and Jeffrey Hii

Malaria Journal 2017 16:92

The malaria testing and treatment market in Kinshasa, Democratic Republic of the Congo, 2013

The Democratic Republic of Congo (DRC) is o­ne of the two most leading contributors to the global burden of disease due to malaria. This paper describes the malaria testing and treatment market in the nation’s …

Godéfroid Mpanya, Antoinette Tshefu and Joris Losimba Likwela

Malaria Journal 2017 16:94

Long-term acceptability, durability and bio-efficacy of ZeroVector^® durable lining for vector control in Papua New Guinea

This study examined the acceptability, durability and bio‐efficacy of pyrethroid‐impregnated durable lining (DL) over a three‐year period post‐installation in residential homes across Papua New Guinea (PNG).

Joseph J. Kuadima, Lincoln Timinao, Laura Naidi, Anthony Tandrapah, Manuel W. Hetzel, Cyrille Czeher and Justin Pulford

Malaria Journal 2017 16:93

Bites before and after bedtime can carry a high risk of human malaria infection

Understanding biting distribution of potentially infectious (parous) mosquitoes at various hours of the night would be useful in establishing the likely impact of bed nets o­n malaria transmission. Bed nets are…

Masabho P. Milali, Maggy T. Sikulu‐Lord and Nicodem J. Govella

Malaria Journal 2017 16:91

MinorityReport, software for generalized analysis of causal genetic variants

The widespread availability of next generation genome sequencing technologies has enabled a wide range of variant detection applications, especially in cancer and inborn genetic disorders. For model systems an…

Jeremy A. Horst, Wesley Wu and Joseph L. DeRisi

Malaria Journal 2017 16:90

Malaria parasite clearance

Following anti‐malarial drug treatment asexual malaria parasite killing and clearance appear to be first order processes. Damaged malaria parasites in circulating erythrocytes are removed from the circulation …

Nicholas J. White

Malaria Journal 2017 16:88

Integrating malaria surveillance with climate data for outbreak detection and forecasting: the EPIDEMIA system

Early indication of an emerging malaria epidemic can provide an opportunity for proactive interventions. Challenges to the identification of nascent malaria epidemics include obtaining recent epidemiological s…

Christopher L. Merkord, Yi Liu, Abere Mihretie, Teklehaymanot Gebrehiwot, Worku Awoke, Estifanos Bayabil, Geoffrey M. Henebry, Gebeyaw T. Kassa, Mastewal Lake and Michael C. Wimberly

Malaria Journal 2017 16:89

Change in Anopheles richness and composition in response to artificial flooding during the creation of the Jirau hydroelectric dam in Porto Velho, Brazil

Anopheles mosquitoes are the o­nly vectors of human malaria. Anopheles species use standing water as breeding sites. Human activities, like the creation of an artificial lake during the…

Moreno S. Rodrigures, Elis P. Batista, Alexandre A. Silva, Fábio M. Costa, Verissimo A. S. Neto and Luiz Herman S. Gil

Malaria Journal 2017 16:87

Developing global maps of insecticide resistance risk to improve vector control

Significant reductions in malaria transmission have been achieved over the last 15 years with elimination occurring in a small number of countries, however, increasing drug and insecticide resistance threatens…

Michael Coleman, Janet Hemingway, Katherine Ann Gleave, Antoinette Wiebe, Peter W. Gething and Catherine L. Moyes

Malaria Journal 2017 16:86

Geographical distributions of African malaria vector sibling species and evidence for insecticide resistance

Many of the mosquito species responsible for malaria transmission belong to a sibling complex; a taxonomic group of morphologically identical, closely related species. Sibling species often differ in several i…

Antoinette Wiebe, Joshua Longbottom, Katherine Gleave, Freya M. Shearer, Marianne E. Sinka, N. Claire Massey, Ewan Cameron, Samir Bhatt, Peter W. Gething, Janet Hemingway, David L. Smith, Michael Coleman and Catherine L. Moyes

Malaria Journal 2017 16:85

Changing the policy for intermittent preventive treatment with sulfadoxine–pyrimethamine during pregnancy in Malawi

The growing resistance of Plasmodium falciparum to sulfadoxine‐pyrimethamine (SP) treatment for uncomplicated malaria led to a recommendation by the World Health Organization for the use of artemisinin‐based comb…

Chikondi A. Mwendera, Christiaan de Jager, Herbert Longwe, Kamija Phiri, Charles Hongoro and Clifford M. Mutero

Malaria Journal 2017 16:84

Anti-malarial effect of novel chloroquine derivatives as agents for the treatment of malaria

The widespread emergence of anti‐malarial drug resistance has necessitated the discovery of novel anti‐malarial drug candidates. In this study, chloroquine derivatives were evaluated for the improved anti‐mala…

Seon‐Ju Yeo, Dong‐Xu Liu, Hak Sung Kim and Hyun Park

Malaria Journal 2017 16:80

Experimental hut evaluation of a novel long-lasting non-pyrethroid durable wall lining for control of pyrethroid-resistant Anopheles gambiae and Anopheles funestus in Tanzania

A novel, insecticide‐treated, durable wall lining (ITWL), which mimics indoor residual spraying (IRS), has been developed to provide prolonged vector control when fixed to the inner walls of houses. PermaNet^® ITW…

Robert Malima, Basiliana Emidi, Louisa A. Messenger, Richard M. Oxborough, Bernard Batengana, Wema Sudi, Sophie Weston, George Mtove, Joseph P. Mugasa, Franklin W. Mosha, Mark W. Rowland and William Kisinza

Malaria Journal 2017 16:82

Local constraints to access appropriate malaria treatment in the context of parasite resistance in Cambodia: a qualitative study

Despite emerging drug resistance in Cambodia, artemisinin‐based combination therapy (ACT) is still the most efficacious therapy. ACT is available free of charge in the Cambodian public sector and at a subsidiz…

Jesse Verschuere, Tom Decroo, Dara Lim, Jean‐Marie Kindermans, Chea Nguon, Rekol Huy, Yasmine Alkourdi, Koen Peeters Grietens and Charlotte Gryseels

Malaria Journal 2017 16:81

Diversity and distribution of avian malaria and related haemosporidian parasites in captive birds from a Brazilian megalopolis

The role of zoos in conservation programmes has increased significantly in last decades, and the health of captive animals is essential to guarantee success of such programmes. However, zoo birds suffer from p…

Carolina Romeiro Fernandes Chagas, Gediminas Valkiūnas, Lilian de Oliveira Guimarães, Eliana Ferreira Monteiro, Fernanda Junqueira Vaz Guida, Roseli França Simões, Priscila Thihara Rodrigues, Expedito José de Albuquerque Luna and Karin Kirchgatter

Malaria Journal 2017 16:83

A novel Pfs38 protein complex o­n the surface of Plasmodium falciparum blood-stage merozoites

The Plasmodium genome encodes for a number of 6‐Cys proteins that contain a module of six cysteine residues forming three intramolecular disulphide bonds. These proteins have been well characterized at transmissi…

Gourab Paul, Arunaditya Deshmukh, Inderjeet Kaur, Sumit Rathore, Surbhi Dabral, Ashutosh Panda, Susheel Kumar Singh, Asif Mohmmed, Michael Theisen and Pawan Malhotra

Malaria Journal 2017 16:79

WHO cone bio-assays of classical and new-generation long-lasting insecticidal nets call for innovative insecticides targeting the knock-down resistance mechanism in Benin

To increase the effectiveness of insecticide‐treated nets (ITN) in areas of high resistance, new long‐lasting insecticidal nets (LLINs) called new‐generation nets have been developed. These nets are treated wi…

Marius Allossogbe, Virgile Gnanguenon, Boulais Yovogan, Bruno Akinro, Rodrigue Anagonou, Fiacre Agossa, André Houtoukpe, Germain Gil Padonou and Martin Akogbeto

Malaria Journal 2017 16:77

Alternative transmission routes in the malaria elimination era: an overview of transfusion-transmitted malaria in the Americas

Transfusion‐transmitted (TT) malaria is an alternative infection route that has gained little attention from authorities, despite representing a life‐threatening condition. There has been no systematic review …

Regina M. Alho, Kim Vinícius Amaral Machado, Fernando F. A. Val, Nelson A. Fraiji, Marcia A. A. Alexandre, Gisely C. Melo, Judith Recht, André M. Siqueira, Wuelton M. Monteiro and Marcus V. G. Lacerda

Malaria Journal 2017 16:78

Molecular evidence of Plasmodium vivax infection in Duffy negative symptomatic individuals from Dschang, West Cameroon

Plasmodium vivax infection is known to be rare in West/Central Africa, the most accepted explanation being the lack of expression of erythroid Duffy antigen in the local human populati…

Gianluca Russo, Giovanni Faggioni, Giacomo Maria Paganotti, Ghyslaine Bruna Djeunang Dongho, Alice Pomponi, Riccardo De Santis, Gianpiero Tebano, Mpoame Mbida, Martin Sanou Sobze, Vincenzo Vullo, Giovanni Rezza and Florigio Romano Lista

Malaria Journal 2017 16:74

Community engagement and the social context of targeted malaria treatment: a qualitative study in Kayin (Karen) State, Myanmar

The spread of artemisinin‐resistance in Plasmodium falciparum is a threat to current global malaria control initiatives. Targeted malaria treatment (TMT), which combines mass anti‐malarial administration with con…

Kate Sahan, Christopher Pell, Frank Smithuis, Aung Kyaw Phyo, Sai Maung Maung, Chanida Indrasuta, Arjen M. Dondorp, Nicholas J. White, Nicholas P. J. Day, Lorenz von Seidlein and Phaik Yeong Cheah

Malaria Journal 2017 16:75

The effect of elevated temperatures o­n the life history and insecticide resistance phenotype of the major malaria vector Anopheles arabiensis (Diptera: Culicidae)

Temperature plays a crucial role in the life history of insects. Recent climate change research has highlighted the importance of elevated temperature o­n malaria vector distribution. This study aims to examine…

Shüné V. Oliver and Basil D. Brooke

Malaria Journal 2017 16:73

Referral of children seeking care at private health facilities in Uganda

In Uganda, referral of sick children seeking care at public health facilities is poor and widely reported. However, studies focusing o­n the private health sector are scanty. The main objective of this study wa…

Anthony K. Mbonye, Esther Buregyeya, Elizeus Rutebemberwa, Siân E. Clarke, Sham Lal, Kristian S. Hansen, Pascal Magnussen and Philip LaRussa

Malaria Journal 2017 16:76

Analysing trends and forecasting malaria epidemics in Madagascar using a sentinel surveillance network: a web-based application

The use of a malaria early warning system (MEWS) to trigger prompt public health interventions is a key step in adding value to the epidemiological data routinely collected by sentinel surveillance systems.

Florian Girond, Laurence Randrianasolo, Lea Randriamampionona, Fanjasoa Rakotomanana, Milijaona Randrianarivelojosia, Maherisoa Ratsitorahina, Télesphore Yao Brou, Vincent Herbreteau, Morgan Mangeas, Sixte Zigiumugabe, Judith Hedje, Christophe Rogier and Patrice Piola

Malaria Journal 2017 16:72

Cellulose filtration of blood from malaria patients for improving ex vivo growth of Plasmodium falciparum parasites

Establishing in vitro Plasmodium falciparum culture lines from patient parasite isolates can offer deeper understanding of geographic variations of drug sensitivity and mechanisms of malaria pathogenesis and imm…

Sixbert I. Mkumbaye, Daniel T. R. Minja, Jakob S. Jespersen, Michael Alifrangis, Reginald A. Kavishe, Steven B. Mwakalinga, John P. Lusingu, Thor G. Theander, Thomas Lavstsen and Christian W. Wang

Malaria Journal 2017 16:69

Avidity of anti-malarial antibodies inversely related to transmission intensity at three sites in Uganda

People living in malaria endemic areas acquire protection from severe malaria quickly, but protection from clinical disease and control of parasitaemia is acquired o­nly after many years of repeated infections….

Isaac Ssewanyana, Emmanuel Arinaitwe, Joaniter I. Nankabirwa, Adoke Yeka, Richard Sullivan, Moses R. Kamya, Philip J. Rosenthal, Grant Dorsey, Harriet Mayanja‐Kizza, Chris Drakeley, Bryan Greenhouse and Kevin K. A. Tetteh

Malaria Journal 2017 16:67

New potential Plasmodium brasilianum hosts: tamarin and marmoset monkeys (family Callitrichidae)

Non‐human primates (NHPs) as a source for Plasmodium infections in humans are a challenge for malaria elimination. In Brazil, two species of Plasmodium have been described infecting NHPs, Plasmodium brasilianum a…

Denise A. M. Alvarenga, Anielle Pina‐Costa, Cesare Bianco, Silvia B. Moreira, Patricia Brasil, Alcides Pissinatti, Claudio T. Daniel‐Ribeiro and Cristiana F. A. Brito

Malaria Journal 2017 16:71

Malaria risk in young male travellers but local transmission persists: a case–control study in low transmission Namibia

A key component of malaria elimination campaigns is the identification and targeting of high risk populations. To characterize high risk populations in north central Namibia, a prospective health facility‐bas…

Jennifer L. Smith, Joyce Auala, Erastus Haindongo, Petrina Uusiku, Roly Gosling, Immo Kleinschmidt, Davis Mumbengegwi and Hugh J. W. Sturrock

Malaria Journal 2017 16:70

Spectrum-Malaria: a user-friendly projection tool for health impact assessment and strategic planning by malaria control programmes in sub-Saharan Africa

Scale‐up of malaria prevention and treatment needs to continue but national strategies and budget allocations are not always evidence‐based. This article presents a new modelling tool projecting malaria infect…

Matthew Hamilton, Guy Mahiane, Elric Werst, Rachel Sanders, Olivier Briët, Thomas Smith, Richard Cibulskis, Ewan Cameron, Samir Bhatt, Daniel J. Weiss, Peter W. Gething, Carel Pretorius and Eline L. Korenromp

Malaria Journal 2017 16:68

Pre-travel malaria chemoprophylaxis counselling in a public travel medicine clinic in São Paulo, Brazil

Malaria is o­ne of the most prevalent parasitic diseases in the world and represents a threat to travellers visiting endemic areas. Chemoprophylaxis is the prevention measure used in travel medicine, avoiding c…

Tânia do Socorro Souza Chaves, Wuelton Marcelo Monteiro, Jessé Reis Alves, Marcus Lacerda and Marta Heloisa Lopes

Malaria Journal 2017 16:64

The role of grass volatiles o­n oviposition site selection by Anopheles arabiensis and Anopheles coluzzii

The reproductive success and population dynamics, of Anopheles malaria mosquitoes is strongly influenced by the oviposition site selection of gravid females. Mosquitoes select oviposition sites at different spati…

Yelfwagash Asmare, Sharon R. Hill, Richard J. Hopkins, Habte Tekie and Rickard Ignell

Malaria Journal 2017 16:65

Malaria from hyperendemicity to elimination in Hekou County o­n China–Vietnam border: an ecological study

Malaria control and elimination are challenged by diversity and complexity of the determinants o­n the international border in the Great Mekong Sub‐region. Hekou, a Chinese county o­n the China‐Vietnam border, w…

Jian‐Wei Xu, Jian‐Jie Li, Hong‐Ping Guo, Shu‐Wei Pu, Shu‐Mei Li, Rong‐Hua Wang, Hui Liu and Wei‐Jia Wang

Malaria Journal 2017 16:66

An epidemiological study to assess Plasmodium falciparum parasite prevalence and malaria control measures in Burkina Faso and Senegal

Malariometric information is needed to decide how to introduce malaria vaccines and evaluate their impact in sub‐Saharan African countries.

Aldiouma Diallo, Ali Sié, Sodiomon Sirima, Khadime Sylla, Mahmadou Ndiaye, Mamadou Bountogo, Espérance Ouedraogo, Roger Tine, Assane Ndiaye, Boubacar Coulibaly, Alphonse Ouedraogo, Babacar Faye, El Hadji Ba, Guillaume Compaore, Alfred Tiono, Cheikh Sokhna…

Malaria Journal 2017 16:63

Reduced ex vivo susceptibility of Plasmodium falciparum after oral artemether–lumefantrine treatment in Mali

Artemisinin‐based combination therapy is the recommended first‐line treatment for uncomplicated falciparum malaria worldwide. However, recent studies conducted in Mali showed an increased frequency of recurren…

Souleymane Dama, Hamidou Niangaly, Amed Ouattara, Issaka Sagara, Sekou Sissoko, Oumar Bila Traore, Amadou Bamadio, Niawanlou Dara, Moussa Djimde, Mohamed Lamine Alhousseini, Siaka Goita, Hamma Maiga, Antoine Dara, Ogobara K. Doumbo and Abdoulaye A. Djimde

Malaria Journal 2017 16:59

Increase in imported malaria in the Netherlands in asylum seekers and VFR travellers

Malaria is a notifiable disease in the Netherlands, a non‐endemic country. Imported malaria infections occur regularly among travellers, migrants and visitors. Surveillance data were analysed from 2008 to 2015…

Brechje de Gier, Franciska S. T. Suryapranata, Mieke Croughs, Perry J. J. van Genderen, Monique Keuter, Leo G. Visser, Michele van Vugt and Gerard J. B. Sonder

Genetic diversity of Plasmodium vivax metacaspase 1 and Plasmodium vivax multi-drug resistance 1 genes of field isolates from Mauritania, Sudan and Oman

Plasmodium vivax is the second most important human malaria parasite, widely spread across the world. This parasite is associated with important issues in the process toward malaria el…

Fatimata Sow, Guillaume Bonnot, Bilal Rabah Ahmed, Sidi Mohamed Diagana, Hachim Kebe, Mohamedou Koita, Ba Malado Samba, Said K. Al‐Mukhaini, Majed Al‐Zadjali, Seif S. Al‐Abri, Osama A. M. Ali, Abdallah M. Samy, Muzamil Mahdi Abdel Hamid, Musab M. Ali Albsheer, Bruno Simon, Anne‐Lise Bienvenu…

Malaria Journal 2017 16:61

Efficacy of artemether–lumefantrine, artesunate–amodiaquine, and dihydroartemisinin–piperaquine for treatment of uncomplicated Plasmodium falciparum malaria in Angola, 2015

Recent anti‐malarial resistance monitoring in Angola has shown efficacy of artemether‐lumefantrine (AL) in certain sites approaching the key 90% lower limit of efficacy recommended for artemisinin‐based combin…

Mateusz M. Plucinski, Pedro Rafael Dimbu, Aleixo Panzo Macaia, Carolina Miguel Ferreira, Claudete Samutondo, Joltim Quivinja, Marília Afonso, Richard Kiniffo, Eliane Mbounga, Julia S. Kelley, Dhruviben S. Patel, Yun He, Eldin Talundzic, Denise O. Garrett, Eric S. Halsey, Venkatachalam Udhayakumar…

Malaria Journal 2017 16:62

Individuals living in a malaria-endemic area of Cameroon do not have an acquired antibody response to Plasmodium falciparum histidine-rich protein 2

Diagnosis of Plasmodium falciparum is often based o­n detection of histidine‐rich protein 2 (HRP2) in blood. Most HRP2‐based assays have high sensitivity and specificity; however, authors have suggested that antib…

Diane Wallace Taylor, Naveen Bobbili, Vedbar S. Khadka, Isabella A. Quakyi and Rose G. F. Leke

Malaria Journal 2017 16:58

Malaria control and prevention towards elimination: data from an eleven-year surveillance in Shandong Province, China

Shandong Province experienced a declining malaria trend of local‐acquired transmission, but the increasing imported malaria remains a challenge. Therefore, understanding the epidemiological characteristics of …

Xiangli Kong, Xin Liu, Hong Tu, Yan Xu, Jianbing Niu, Yongbin Wang, Changlei Zhao, Jingxuan Kou and Jun Feng

Malaria Journal 2017 16:55

Adapting the local response for malaria elimination through evaluation of the 1-3-7 system performance in the China–Myanmar border region

Assessing the essential components of ‘1‐3‐7’ strategy along the China‐Myanmar border is critical to identify gaps and challenges to support evidence‐based decision making.

Duoquan Wang, Chris Cotter, Xiaodong Sun, Adam Bennett, Roly D. Gosling and Ning Xiao

Malaria Journal 2017 16:54

Submicroscopic Plasmodium prevalence in relation to malaria incidence in 20 villages in western Cambodia

Cambodia has seen a marked reduction in the incidence of Plasmodium falciparum over the past decade without a corresponding decline in Plasmodium vivax incidence. It is unknown to what extent local transmission i…

Rupam Tripura, Thomas J. Peto, Christianne C. Veugen, Chea Nguon, Chan Davoeung, Nicola James, Mehul Dhorda, Richard J. Maude, Jureeporn Duanguppama, Krittaya Patumrat, Mallika Imwong, Lorenz von Seidlein, Martin P. Grobusch, Nicholas J. White and Arjen M. Dondorp

Malaria Journal 2017 16:56

Describing interaction effect between lagged rainfalls o­n malaria: an epidemiological study in south–west China

When discussing the relationship between meteorological factors and malaria, previous studies mainly focus o­n the interaction between different climatic factors, while the possible interaction within o­ne parti…

Yunyun Wu, Zhijiao Qiao, Nan Wang, Hongjie Yu, Zijian Feng, Xiaosong Li and Xing Zhao

Malaria Journal 2017 16:53

Severe malaria in Europe: an 8-year multi-centre observational study

Malaria remains o­ne of the most serious infections for travellers to tropical countries. Due to the lack of harmonized guidelines a large variety of treatment regimens is used in Europe to treat severe malaria.

Florian Kurth, Michel Develoux, Matthieu Mechain, Denis Malvy, Jan Clerinx, Spinello Antinori, Ida E. Gjørup, Joaquím Gascon, Kristine Mørch, Emanuele Nicastri, Michael Ramharter, Alessandro Bartoloni, Leo Visser, Thierry Rolling, Philipp Zanger, Guido Calleri…

Malaria Journal 2017 16:57

Severe Plasmodium vivax infection in Korea

Although severe malaria by Plasmodium vivax has been increasingly reported, there are marked variations in the type and rate of the complications by geographic area. This is possibly because of the presence of co…

Jae Hyoung Im, Hea Yoon Kwon, JiHyeon Baek, Seong Wook Park, Areum Durey, Kyung Hee Lee, Moon‐Hyun Chung and Jin‐Soo Lee

Malaria Journal 2017 16:51

Effect of a short course of iron polymaltose o­n acquisition of malarial parasitaemia in anaemic Indonesian schoolchildren: a randomized trial

Concern exists about the safety of iron supplementation given to individuals in malarious areas. The possible unfavourable impact of iron supplementation o­n malaria might be less when slow‐release iron compoun…

Margaretta A. Prasetyani, Quirijn de Mast, Robel Afeworki, Maria M. M. Kaisar, Difa Stefanie, Erliyani Sartono, Taniawati Supali and André J. van der Ven

Malaria Journal 2017 16:50

Working towards consensus o­n methods used to elicit participant-reported safety data in uncomplicated malaria clinical drug studies: a Delphi technique study

Eliciting adverse event (AE) and non‐study medication data reports from clinical research participants is integral to evaluating drug safety. However, using different methods to question participants yields i…

Nyaradzo Mandimika, Karen I. Barnes, Clare I. R. Chandler, Cheryl Pace and Elizabeth N. Allen

Malaria Journal 2017 16:52

Health Impact Assessment of Indira Sagar Project: a paramount to studies o­n Water Development Projects

Very limited studies o­n Health Impact Assessment (HIA) of Water Development Projects (WDP) in relation to mosquito‐borne diseases have been carried out in India. The current study focuses o­n using HIA as a too…

Anushrita, B. N. Nagpal, Neera Kapoor, Aruna Srivastava, Rekha Saxena, Shailendra Singh, Sanjeev Gupta, Sompal Singh, Kumar Vikram and Neena Valecha

Malaria Journal 2017 16:47

Serology reveals heterogeneity of Plasmodium falciparum transmission in northeastern South Africa: implications for malaria elimination

It is widely acknowledged that modifications to existing control interventions are required if South Africa is to achieve malaria elimination. Targeting indoor residual spraying (IRS) to areas where cases have…

Joseph Biggs, Jaishree Raman, Jackie Cook, Khumbulani Hlongwana, Chris Drakeley, Natashia Morris, Ishen Serocharan, Eunice Agubuzo, Philip Kruger, Aaron Mabuza, Alpheus Zitha, Elliot Machaba, Maureen Coetzee and Immo Kleinschmidt

Malaria Journal 2017 16:48

The impact of urbanization and population density o­n childhood Plasmodium falciparum parasite prevalence rates in Africa

Although malaria has been traditionally regarded as less of a problem in urban areas compared to neighbouring rural areas, the risk of malaria infection continues to exist in densely populated, urban areas of …

Caroline W. Kabaria, Marius Gilbert, Abdisalan M. Noor, Robert W. Snow and Catherine Linard

Malaria Journal 2017 16:49

Artemether-lumefantrine and liver enzyme abnormalities in non-severe Plasmodium falciparum malaria in returned travellers: a retrospective comparative study with quinine-doxycycline in a Portuguese centre

Artemisinin‐based therapy is the current standard treatment for non‐severe malaria due to Plasmodium falciparum. The potential for asymptomatic liver toxicity of this therapy and its implication in clinical prac…

André Silva‐Pinto, Rogério Ruas, Francisco Almeida, Raquel Duro, André Silva, Cândida Abreu and António Sarmento

Malaria Journal 2017 16:43

In vitro activity of anti-malarial ozonides against an artemisinin-resistant isolate

Recently published data suggest that artemisinin derivatives and synthetic peroxides, such as the ozonides OZ277 and OZ439, have a similar mode of action. Here the cross‐resistance of OZ277 and OZ439 and four …

Fabian Baumgärtner, Joëlle Jourdan, Christian Scheurer, Benjamin Blasco, Brice Campo, Pascal Mäser and Sergio Wittlin

Malaria Journal 2017 16:45

Efficacy of text-message reminders o­n paediatric malaria treatment adherence and their post-treatment return to health facilities in Kenya: a randomized controlled trial

Short Message Service (SMS) reminders have been suggested as a potential intervention for improving adherence to medications and health facility attendance.

Ambrose O. Talisuna, Amos Oburu, Sophie Githinji, Josephine Malinga, Beatrice Amboko, Philip Bejon, Caroline Jones, Robert W. Snow and Dejan Zurovac

Malaria Journal 2017 16:46

Response to fever and utilization of standby emergency treatment (SBET) for malaria in travellers to Southeast Asia: a questionnaire-based cohort study

Guidelines in several European countries recommend standby emergency treatment (SBET) for travellers to regions with low or medium malaria transmission instead of continuous chemoprophylaxis: travellers are ad…

Christof D. Vinnemeier, Camilla Rothe, Benno Kreuels, Marylyn M. Addo, Sabine Vygen‐Bonnet, Jakob P. Cramer and Thierry Rolling

Malaria Journal 2017 16:44

On the cytokine/chemokine network during Plasmodium vivax malaria: new insights to understand the disease

The clinical outcome of malaria depends o­n the delicate balance between pro‐inflammatory and immunomodulatory cytokine responses triggered during infection. Despite the numerous reports o­n characterization of …

Natália Satchiko Hojo‐Souza, Dhelio Batista Pereira, Fernanda Sumika Hojo de Souza, Tiago Antônio de Oliveira Mendes, Mariana Santos Cardoso, Mauro Shugiro Tada, Graziela Maria Zanini, Daniella Castanheira Bartholomeu, Ricardo Toshio Fujiwara and Lilian Lacerda Bueno

Malaria Journal 2017 16:42

Optimization of mosquito egg production under mass rearing setting: effects of cage volume, blood meal source and adult population density for the malaria vector, Anopheles arabiensis

Anopheles arabiensis is o­ne of the major malaria vectors that put millions of people in endemic countries at risk. Mass‐rearing of this mosquito is crucial for strategies that use ster…

Wadaka Mamai, Nanwintoum S. Bimbile‐Somda, Hamidou Maiga, José Guillermo Juarez, Zaynab A. I. Muosa, Adel Barakat Ali, Rosemary Susan Lees and Jeremie R. L. Gilles

Malaria Journal 2017 16:41

Recent uptake of intermittent preventive treatment during pregnancy with sulfadoxine–pyrimethamine is associated with increased prevalence of Pfdhfr mutations in Bobo-Dioulasso, Burkina Faso

The impact of sulfadoxine‐pyrimethamine (SP) used as intermittent preventive treatment during pregnancy (IPTp‐SP) o­n mutant parasite selection has been poorly documented in Burkina Faso. This study sought firs…

Mamoudou Cisse, Gordon A. Awandare, Alamissa Soulama, Halidou Tinto, Marie‐Pierre Hayette and Robert T. Guiguemdé

Malaria Journal 2017 16:38

A(maize)ing attraction: gravid Anopheles arabiensis are attracted and oviposit in response to maize pollen odours

Maize cultivation contributes to the prevalence of malaria mosquitoes and exacerbates malaria transmission in sub‐Saharan Africa. The pollen from maize serves as an important larval food source for Anopheles mosq…

Betelehem Wondwosen, Sharon R. Hill, Göran Birgersson, Emiru Seyoum, Habte Tekie and Rickard Ignell

Malaria Journal 2017 16:39

Health worker adherence to malaria treatment guidelines at outpatient health facilities in southern Malawi following implementation of universal access to diagnostic testing

Appropriate diagnosis and treatment are essential for reducing malaria mortality. A cross‐sectional outpatient health facility (HF) survey was conducted in southern Malawi from January to March 2015 to determi…

Ruth J. Namuyinga, Dyson Mwandama, Dubulao Moyo, Austin Gumbo, Peter Troell, Miwako Kobayashi, Monica Shah, Andrew Bauleni, Jodi Vanden Eng, Alexander K. Rowe, Don P. Mathanga and Laura C. Steinhardt

Malaria Journal 2017 16:40

Development of Plasmodium falciparum specific naïve, atypical, memory and plasma B cells during infancy and in adults in an endemic area

B‐cells are essential in immunity against malaria, but which sub‐sets of B‐cells specifically recognize Plasmodium falciparum and when they appear is still largely unknown.

Allan Lugaajju, Sreenivasulu B. Reddy, Mats Wahlgren, Fred Kironde and Kristina E. M. Persson

Malaria Journal 2017 16:37

Performance of loop-mediated isothermal amplification (LAMP) for the diagnosis of malaria among malaria suspected pregnant women in Northwest Ethiopia

Malaria is a major public health problem and an important cause of maternal and infant morbidity in sub‐Saharan Africa, including Ethiopia. Early and accurate diagnosis of malaria with effective treatment is t…

Banchamlak Tegegne, Sisay Getie, Wossenseged Lemma, Abu Naser Mohon and Dylan R. Pillai

Malaria Journal 2017 16:34

Heterogeneity of G6PD deficiency prevalence in Mozambique: a school-based cross-sectional survey in three different regions

Glucose‐6‐phosphate dehydrogenase (G6PD) deficiency is an X‐linked hereditary enzymatic abnormality that affects more than 400 million people worldwide. Most deficient individuals do not manifest any symptoms;…

Beatriz Galatas, Lurdes Mabote, Wilson Simone, Gloria Matambisso, Lidia Nhamussua, María del Mar Mañú‐Pereira, Clara Menéndez, Francisco Saute, Eusebio Macete, Quique Bassat, Pedro Alonso and Pedro Aide

Malaria Journal 2017 16:36

Assessing the availability of LLINs for continuous distribution through routine antenatal care and the Expanded Programme o­n Immunizations in sub-Saharan Africa

In addition to mass distribution campaigns, the World Health Organization (WHO) recommends the continuous distribution of long‐lasting insecticidal nets (LLINs) to all pregnant women attending antenatal care (…

Katherine Theiss‐Nyland, Michael Lynch and Jo Lines

Malaria Journal 2016 15:255

Cellular engineering of Artemisia annua and Artemisia dubia with the rol ABC genes for enhanced production of potent anti-malarial drug artemisinin

Malaria is causing more than half of a million deaths and 214 million clinical cases annually. Despite tremendous efforts for the control of malaria, the global morbidity and mortality have not been significan…

Bushra Hafeez Kiani, John Suberu and Bushra Mirza

Malaria Journal 2016 15:252

The importance of accounting for larval detectability in mosquito habitat-association studies

Mosquito habitat‐association studies are an important basis for disease control programmes and/or vector distribution models. However, studies do not explicitly account for incomplete detection during larval p…

Matthew Low, Admasu Tassew Tsegaye, Rickard Ignell, Sharon Hill, Rasmus Elleby, Vilhelm Feltelius and Richard Hopkins

Malaria Journal 2016 15:253

Plasmodium falciparum malaria parasitaemia among indigenous Batwa and non-indigenous communities of Kanungu district, Uganda

The indigenous Batwa of southwestern Uganda are among the most highly impoverished populations in Uganda, yet there is negligible research o­n the prevalence of malaria in this population. Plasmodium falciparum ma…

Blánaid Donnelly, Lea Berrang‐Ford, Jolène Labbé, Sabastian Twesigomwe, Shuaib Lwasa, Didacus B. Namanya, Sherilee L. Harper, Manisha Kulkarni, Nancy A. Ross and Pascal Michel

Malaria Journal 2016 15:254

Assessing the effects of mosquito nets o­n malaria mortality using a space time model: a case study of Rufiji and Ifakara Health and Demographic Surveillance System sites in rural Tanzania

Although malaria decline has been observed in most sub‐Saharan African countries, the disease still represents a significant public health burden in Tanzania. There are contradictions o­n the effect of ownershi…

Majige Selemani, Amina S. Msengwa, Sigilbert Mrema, Amri Shamte, Michael J. Mahande, Karen Yeates, Maurice C. Y. Mbago and Angelina M. Lutambi

Malaria Journal 2016 15:257

Mortality and pathology in birds due to Plasmodium (Giovannolaia) homocircumflexum infection, with emphasis o­n the exoerythrocytic development of avian malaria parasites

Species of avian malaria parasites (Plasmodium) are widespread, but their virulence has been insufficiently investigated, particularly in wild birds. During avian malaria, several cycles of tissue merogony occur,…

Mikas Ilgūnas, Dovilė Bukauskaitė, Vaidas Palinauskas, Tatjana A. Iezhova, Nora Dinhopl, Nora Nedorost, Christiane Weissenbacher‐Lang, Herbert Weissenböck and Gediminas Valkiūnas

Malaria Journal 2016 15:256

Development of a Plasmodium berghei transgenic parasite expressing the full-length Plasmodium vivax circumsporozoite VK247 protein for testing vaccine efficacy in a murine model

The approach of using transgenic rodent malaria parasites to assess the immune system’s response to antigenic targets from a human malaria parasite has been shown to be useful for preclinical evaluation of new…

Masanori Mizutani, Shinya Fukumoto, Adam Patrice Soubeiga, Akira Soga, Mitsuhiro Iyori and Shigeto Yoshida

Malaria Journal 2016 15:251

Evaluation of intensified behaviour change communication strategies in an artemisinin resistance setting

In Cambodia, behaviour change communication (BCC) represents an integral component of malaria efforts aimed at fighting artemisinin resistant parasites and achieving elimination. The multi‐pronged BCC interven…

Sara E. Canavati, Celine Zegers de Beyl, Po Ly, Muhammad Shafique, Thavrin Boukheng, Chandary Rang, Maxine Anne Whittaker, Arantxa Roca‐Feltrer and David Sintasath

Malaria Journal 2016 15:249

Analysis of asymptomatic and clinical malaria in urban and suburban settings of southwestern Ethiopia in the context of sustaining malaria control and approaching elimination

Malaria intervention in Ethiopia has been strengthened significantly in the past decade. The Ethiopian government recently stratified the country based upon annual parasite incidence into malaria free, low, mo…

Guofa Zhou, Delenasaw Yewhalaw, Eugenia Lo, Daibin Zhong, Xiaoming Wang, Teshome Degefa, Endalew Zemene, Ming‐chieh Lee, Estifanos Kebede, Kora Tushune and Guiyun Yan

Malaria Journal 2016 15:250

Monitoring iCCM referral systems: Bugoye Integrated Community Case Management Initiative (BIMI) in Uganda

In Uganda, over half of under‐five child mortality is attributed to three infectious diseases: malaria, pneumonia and diarrhoea. Integrated community case management (iCCM) trains village health workers (VHWs)…

Lacey English, James S. Miller, Rapheal Mbusa, Michael Matte, Jessica Kenney, Shem Bwambale, Moses Ntaro, Palka Patel, Edgar Mulogo and Geren S. Stone

Malaria Journal 2016 15:247

Characterization of an A-kinase anchoring protein-like suggests an alternative way of PKA anchoring in Plasmodium falciparum

The asexual intra‐erythrocytic multiplication of the malaria parasite Plasmodium falciparum is regulated by various molecular mechanisms. In eukaryotic cells, protein kinases are known to play key roles in cell c…

Kossiwa Bandje, Bernina Naissant, Pascal Bigey, Murielle Lohezic, Marlène Vayssières, Magali Blaud, Laetitia Kermasson, José‐Juan Lopez‐Rubio, Gordon Langsley, Catherine Lavazec, Philippe Deloron and Anaïs Merckx

Malaria Journal 2016 15:248

How important is the angle of tilt in the WHO cone bioassay?

The World Health Organization (WHO) cone bioassay plays an integral role in the evaluation of the efficacy of long‐lasting insecticidal nets as well as insecticides used in indoor residual spraying. The test i…

Henry F. Owusu and Pie Müller

Malaria Journal 2016 15:243

Pharmacokinetic properties of intramuscular versus oral syrup paracetamol in Plasmodium falciparum malaria

Fever is an inherent symptom of malaria in both adults and children. Paracetamol (acetaminophen) is the recommended antipyretic as it is inexpensive, widely available and has a good safety profile, but patient…

Thanaporn Wattanakul, Pramote Teerapong, Katherine Plewes, Paul N. Newton, Wirongrong Chierakul, Kamolrat Silamut, Kesinee Chotivanich, Ronnatrai Ruengweerayut, Nicholas J. White, Arjen M. Dondorp and Joel Tarning

Malaria Journal 2016 15:244

Risk factors of malaria in children under the age of five years old in Uganda

Malaria is the leading cause of morbidity in Uganda with 90‐95 % of the population at risk and it contributing to approximately 13 % of under‐five mortality. The aim of this study was to investigate the relati…

Danielle Roberts and Glenda Matthews

Malaria Journal 2016 15:246

Heterogeneous malaria transmission in long‐term Afghan refugee populations: a cross‐sectional study in five refugee camps in northern Pakistan

Afghan refugees in northern Pakistan have been resident for over 30 years and current information o­n malaria in this population is sparse. Understanding malaria risk and distribution in refugee camps is import…

Sobia Wahid, Gillian H. Stresman, Syed Sajid Kamal, Nuno Sepulveda, Immo Kleinschmidt, Teun Bousema and Chris Drakeley

Malaria Journal 2016 15:245

History of malaria treatment as a predictor of subsequent subclinical parasitaemia: a cross‐sectional survey and malaria case records from three villages in Pailin, western Cambodia

Treatment of the sub‐clinical reservoir of malaria, which may maintain transmission, could be an important component of elimination strategies. The reliable detection of asymptomatic infections with low levels…

Thomas J. Peto, Sabine E. Kloprogge, Rupam Tripura, Chea Nguon, Nou Sanann, Sovann Yok, Chhouen Heng, Cholrawee Promnarate, Jeremy Chalk, Ngak Song, Sue J. Lee, Yoel Lubell, Mehul Dhorda, Mallika Imwong, Nicholas J. White, Lorenz von Seidlein…

Malaria Journal 2016 15:240

Clustering and genetic differentiation of the normocyte binding protein (nbpxa) of Plasmodium knowlesi clinical isolates from Peninsular Malaysia and Malaysia Borneo

The zoonotic malaria parasite Plasmodium knowlesi has become an emerging threat to South East Asian countries particular in Malaysia. A recent study from Sarawak (Malaysian Borneo) discovered two distinct normocy…

Md Atique Ahmed, Mun Yik Fong, Yee Ling Lau and Ruhani Yusof

Malaria Journal 2016 15:241

Defining rules of CD8+ T cell expansion against pre‐erythrocytic Plasmodium antigens in sporozoite‐immunized mice

Whole Plasmodium sporozoites serve as both experimental tools and potentially as deployable vaccines in the fight against malaria infection. Live sporozoites infect hepatocytes and induce a diverse repertoire of …

Zachary P. Billman, Arnold Kas, Brad C. Stone and Sean C. Murphy

Malaria Journal 2016 15:238

Determination of the foraging behaviour and blood meal source of malaria vector mosquitoes in Trincomalee District of Sri Lanka using a multiplex real time polymerase chain reaction assay

Studies of host preference patterns in blood‐feeding anopheline mosquitoes are crucial to incriminating malaria vectors. However, little information is available o­n host preferences of Anopheles mosquitoes in Sri…

Nayana Gunathilaka, Thanuja Denipitiya, Menaka Hapugoda, Wimaladharma Abeyewickreme and Rajitha Wickremasinghe

Malaria Journal 2016 15:242

Increasing outdoor host‐seeking in Anopheles gambiae over 6 years of vector control o­n Bioko Island

Vector control through indoor residual spraying (IRS) has been employed o­n Bioko Island, Equatorial Guinea, under the Bioko Island Malaria Control Project (BIMCP) since 2004. This study analyses the change in …

Jacob I. Meyers, Sharmila Pathikonda, Zachary R. Popkin‐Hall, Matthew C. Medeiros, Godwin Fuseini, Abrahan Matias, Guillermo Garcia, Hans J. Overgaard, Vani Kulkarni, Vamsi P. Reddy, Christopher Schwabe, Jo Lines, Immo Kleinschmidt and Michel A. Slotman

Malaria Journal 2016 15:239

Malaria case clinical profiles and Plasmodium falciparum parasite genetic diversity: a cross sectional survey at two sites of different malaria transmission intensities in Rwanda

Malaria remains a public health challenge in sub‐Saharan Africa with Plasmodium falciparum being the principal cause of malaria disease morbidity and mortality. Plasmodium falciparum v…

Fredrick Kateera, Sam L. Nsobya, Stephen Tukwasibwe, Petra F. Mens, Emmanuel Hakizimana, Martin P. Grobusch, Leon Mutesa, Nirbhay Kumar and Michele van Vugt

Malaria Journal 2016 15:237

In vivo efficacy of artemether‐lumefantrine and artesunate‐amodiaquine for uncomplicated Plasmodium falciparum malaria in Malawi, 2014

Malaria causes significant morbidity in Malawi, with an estimated 5 million cases in 2014. Artemether‐lumefantrine (AL) and artesunate‐amodiaquine (ASAQ) are the first‐ and second‐line treatments for uncomplic…

Magdalena Paczkowski, Dyson Mwandama, Daniel Marthey, Madalitso Luka, Georgina Makuta, John Sande, Doreen Ali, Peter Troell, Don P. Mathanga and Julie Gutman

Malaria Journal 2016 15:236

The need for operational research and capacity‐building in support of the Global Technical Strategy for Malaria 2016‐2030

Andrew Ramsay, Piero Olliaro and John C. Reeder

Malaria Journal 2016 15:235

Visualization of house‐entry behaviour of malaria mosquitoes

Malaria mosquitoes often blood feed indoors o­n human hosts. The mosquitoes predominantly enter houses via open eaves. Host‐seeking is odour‐driven, and finding a host depends o­n the quality of the odour plume …

Jeroen Spitzen, Teun Koelewijn, W. Richard Mukabana and Willem Takken

Malaria Journal 2016 15:233

Transfusion‐transmitted malaria: donor prevalence of parasitaemia and a survey of healthcare workers knowledge and practices in a district hospital in Ghana

Transfusion‐transmitted malaria (TTM) is a risk of transfusion that has not been well described in malaria endemic regions. The risk of the recipient getting malaria is related to the prevalence of malaria in …

Alex Owusu‐Ofori, Dominic Gadzo and Imelda Bates

Malaria Journal 2016 15:234

Enhanced transmission of malaria parasites to mosquitoes in a murine model of type 2 diabetes

More than half of the world’s population is at risk of malaria and simultaneously, many malaria‐endemic regions are facing dramatic increases in the prevalence of type 2 diabetes. Studies in murine malaria mod…

Nazzy Pakpour, Kong Wai Cheung and Shirley Luckhart

Malaria Journal 2016 15:231

Genomic variation in two gametocyte non‐producing Plasmodium falciparum clonal lines

Transmission of the malaria parasite Plasmodium falciparum from humans to the mosquito vector requires differentiation of a sub‐population of asexual forms replicating within red blood cells into non‐dividing mal…

Susana Campino, Ernest Diez Benavente, Samuel Assefa, Eloise Thompson, Laura G. Drought, Catherine J. Taylor, Zaria Gorvett, Celine K. Carret, Christian Flueck, Al C. Ivens, Dominic P. Kwiatkowski, Pietro Alano, David A. Baker and Taane G. Clark

Malaria Journal 2016 15:229

Assessing the effects of malaria interventions o­n the geographical distribution of parasitaemia risk in Burkina Faso

Burkina Faso conducted its first nationally representative household malaria survey in 2010/2011. The survey collected among others, information o­n malaria interventions, treatment choices and malaria parasite…

Eric Diboulo, Ali Sié and Penelope Vounatsou

Malaria Journal 2016 15:228

An ultrasensitive NanoLuc‐based luminescence system for monitoring Plasmodium berghei throughout its life cycle

Bioluminescence imaging is widely used for cell‐based assays and animal imaging studies, both in biomedical research and drug development. Its main advantages include its high‐throughput applicability, afforda…

Mariana De Niz, Rebecca R. Stanway, Rahel Wacker, Derya Keller and Volker T. Heussler

Malaria Journal 2016 15:232

Chronic malaria and hyper‐reactive malarial splenomegaly: a retrospective study o­n the largest series observed in a non‐endemic country

Chronic malaria is usually defined as a long‐term malarial infection in semi‐immune subjects, usually without fever or other acute symptoms. The untreated infection may evolve to hyper‐reactive malarial spleno…

Zeno Bisoffi, Stefania Leoni, Andrea Angheben, Anna Beltrame, Franklyn Esoka Eseme, Federico Gobbi, Claudia Lodesani, Stefania Marocco and Dora Buonfrate

Malaria Journal 2016 15:230

Pre‐infection administration of asiatic acid retards parasitaemia induction in Plasmodium berghei murine malaria infected Sprague‐Dawley rats

Malaria prevention has remained a critical area in the absence of efficacious vaccines against malaria. Drugs currently used as chemotherapeutics are also used in chemoprophylaxis increasing possible drug resi…

Greanious Alfred Mavondo, Blessing Nkazimulo Mkhwananzi and Musa Vuyisile Mabandla

Malaria Journal 2016 15:226

Determinants of prompt and adequate care among presumed malaria cases in a community in eastern Rwanda: a cross sectional study

In order to understand factors influencing fever/malaria management practices among community‐based individuals, the study evaluated psychosocial, socio‐demographic and environmental determinants of prompt and…

Chantal Marie Ingabire, Fredrick Kateera, Emmanuel Hakizimana, Alexis Rulisa, Claude Muvunyi, Petra Mens, Constantianus J. M. Koenraadt, Leon Mutesa, Michele Van Vugt, Bart Van Den Borne and Jane Alaii

Malaria Journal 2016 15:227