Nhiều ấn phẩm và bài báo gần đây do các nhóm tác giả nghiên cứu về sốt rét rất nổi tiếng trên thế giới đã cho thấy lĩnh vực một lần nữa lại đối mặt nhiều thách thức và nhiều nghiên cứu vẫn chưa giải quyết thỏa đáng các câu hỏi và giới khoa học, đặc biệt các chuyên gia nghiêncứu về sốt rét còn đang tranh luận. Nhiều nhà làm chính sách đi cùng các nhà khoa học đã cho thấy nhiều điểm vẫn còn đang bỏ ngõ và đó chính là các thách thức lớn trong nghiên cứu về sốt rét hiện nay.
This infographic illustrates the key achievements of the project to establish and validate a manufacturing process to produce semisynthetic artemisinin (ssART) at industrial scale and commercialize ssART. Production of ssART aims to supplement a historically volatile botanical supply chain, strengthening the artemisinin market and ensuring that the global need for artemisinin‐based combination therapies can be met, thus supporting current worldwide malaria control measures and strategies for malaria elimination.
Publication date: April 2016; Region: Global;
2. PATH Center for Malaria Control and Elimination
PATH’s Center for Malaria Control and Elimination is building on our unparalleled portfolio of malaria tools and projects, encompassing a broad collection of competencies and expertise, to advance efforts toward elimination, and ultimately eradication, of both P. falciparum and P. vivax malaria.
Publication date: April 2016; Region: Global;
3. Saving Lives in Kenya: Advocating for a Better Future for Women, Newborns, and Children
PATH is working with the government of
Publication date: April 2016; Region: Africa;
This four‐page brochure highlights how PATH accelerates data‐driven innovation to improve health and save lives in
Publication date: January 2016; Region: Africa, Part of series:
5. Country brochures PATH in Tanzania
This four‐page brochure highlights how PATH uses innovation, integration of services, and better data systems to improve health and save lives in
Publication date: January 2016; Region: Africa; Part of series:
6. Country brochures PATH in the Democratic Republic of the Congo
This brochure provides an overview of PATH’s work in the
Publication date: January 2016; Region: Africa; Part of series:
7. Country brochures; Drug Development Global Program Website
This website about PATH’s drug development program provides an overview of the program and its featured projects. See other PATH program websites.
Publication date: 2016; Region: Global; Part of series: Program websites;
8. Ethiopia Country Program Website
This website about PATH’s
Publication date: 2016; Region: Africa; Part of series: Program websites,
9. Making Malaria History Website
This website features updates on the latest malaria research and news, resources for advocates and technical partners, evidence and progress from the global malaria community, and field tools currently being used by countries at the forefront of the fight against the disease.
Publication date: 2016; Region: Africa; Part of series: Websites,
10. Malaria Control and Evaluation Partnership in Africa Global Program Website
This website about PATH’s Malaria Control and Evaluation Partnership in Africa (MACEPA) global program provides an overview of the program and its featured projects. See other PATH program websites.
Publication date: 2016; Region: Global; Part of series: Program websites
11. Malaria Vaccine Initiative Global Program Website
This website about PATH’s Malaria Vaccine Initiative (MVI) global program provides an overview of the program and its featured projects. See other PATH program websites.
Publication date: 2016, Region: Global, Part of series: Program websites,
12. Malaria Vaccine Initiative Website
Launched in 2002, this website provides information on the Malaria Vaccine Initiative at PATH.
Publication date: 2016, Region: Global, Part of series: Websites,
13. Tanzania Country Program Website
This website about PATH’s
Publication date: 2016; Region: Africa; Part of series: Program websites
14. Zambia Country Program Website
This website about PATH’s
Publication date: 2016; Region: Africa; Part of series: Program websites,
This fact sheet describes PATH’s work to eliminate malaria, including expanding the use of lifesaving tools, identifying and developing better diagnostics and drugs, devising new strategies for malaria control, and accelerating the development of malaria vaccines.
Publication date: April 2015; Region: Global; Part of series: Areas of focus fact sheets
16. Driving Development and Adoption of Malaria Diagnostic Tools
PATH is a leader in the innovation, promotion, and adoption of diagnostic technologies to support malaria elimination and ultimately eradication. As a whole, malaria‐related projects and programs at PATH form a core of organizational expertise and strong infrastructure to accelerate the development and adoption of new and improved malaria diagnostics.
Publication date: March 2015; Region: Global,
17. Policies and Actions for Improved Malaria in Pregnancy Efforts in Communities
Emerging evidence in
Publication date: March 2015; Region: Africa;
18. USAID and PATH: Working Together to Improve Global Health
PATH and the US Agency for International Development (USAID) work together to promote and improve health in developing countries. This fact sheet provides examples of successes that PATH, USAID, and our private partners have had in advancing technologies, strengthening health systems, and encouraging healthy behaviors to improve health and allow communities around the world to prosper.
Publication date: January 2015; Region: North America and Europe,
A Healthy Dose from PATH’s Drug Development program gives advocates, policymakers, government and agency leaders, and anyone interested in global health a quarterly update on our work. Each issue features reports from the field, news on the latest clinical trial milestones, and resources in nonprofit drug development.
Publication date: 2015; Region: Global; Part of series: E-newsletters
20. Making Malaria History Newsletter
The Making Malaria History newsletter is a periodic update on activities of the Malaria Control and Evaluation Partnership in
Publication date: 2015;
In
Publication date: October 2014; Region: Africa;
In sub‐Saharan
Publication date: September 2014; Region: Africa;
In sub‐Saharan
Publication date: September 2014; Region: Africa;
Artemisinin‐based combination therapy is considered the gold standard treatment for malaria, but global demand has often outpaced production, and pricing has been volatile. This fact sheet describes the cross‐sector partnership PATH formed to develop a new way to produce high‐quality, nonseasonal, and affordable artemisinin to supplement the plant‐based supply.
Publication date: July 2014; Region: Global;
This fact sheet provides an overview of the work of PATH’s Malaria Control and Elimination Partnership in Africa (MACEPA) to develop and document approaches for reducing malaria illnesses and deaths, with the long‐term goal of malaria elimination.
Publication date: April 2014; Region: Africa;
26. Rapid, Point-of-Care Test for Glucose-6 Phosphate Dehydrogenase Deficiency
Part of the Technology Updates series, this fact sheet describes PATH’s work with diagnostic developers and stakeholders from around the world to develop a rapid, point‐of‐care diagnostic test for glucose‐6 phosphate dehydrogenase (G6PD) deficiency. A reliable test for G6PD at the point of care is essential to malaria elimination strategies.
Publication date: April 2014; Region: Global; Part of series: Technology Updates
27. Semisynthetic Artemisinin: Cross-Sector Partnership to Stabilize the Antimalarial Drug Supply
Artemisinin‐based combination therapy is considered the gold standard treatment for malaria, but global demand has often outpaced production, and pricing has been volatile. With funding from the Bill & Melinda Gates Foundation, PATH and our partners set out to develop a new pharmaceutical manufacturing process to produce commercial volumes of high‐quality, nonseasonal, and affordable artemisinin to supplement the plant‐based supply. This poster, presented at the Bay Area World Malaria Day Symposium on April 25, 2014, presents key facts on malaria, the market for artemisinin, partner roles, and commercial production.
Publication date: April 2014; Region: Global;
28. MalariaCare – Universal Diagnosis and Treatment to Improve Maternal and Child Health
This fact sheet describes the MalariaCare partnership, a five‐year effort led by PATH and funded by the US Agency for International Development and the President’s Malaria Initiative. The project aims to scale up high‐quality diagnosis and treatment services for malaria and other life‐threatening illnesses.
Publication date: January 2014; Region: Global;
29. From Pipeline to Product: Malaria R&D Funding Needs Into the Next Decade
This report, a follow‐on to the 2011 report Staying the Course? Malaria Research and Development in a Time of Economic Uncertainty, tracks malaria research and development funding from 2007 to 2011 and provides estimates on funding needs through 2022.
Publication date: December 2013; Region: Global;
30. Improving Women’s and Children’s Health in Senegal
This fact sheet provides an overview of PATH’s work in
Publication date: December 2013; Region: Africa,
31. Overview of Nucleic Acid–Based Diagnostic Techniques
To support a World Health Organization (WHO) Evidence Review Group on Malaria Diagnostics in Low‐Transmission Settings in December 2013, PATH was invited to provide an overview of polymerase chain reaction and isothermal molecular methods for malaria infection detection. The PowerPoint is provided here and the WHO policy recommendations from the evidence review can be found here.
Author: LaBarre P, Tietje K; Publication date: December 2013; Region: Global;
This fact sheet highlights PATH’s Impact Initiatives. Through these initiatives, cross‐program teams identify high‐priority health areas for improvement, set institutional goals, and then mobilize resources to achieve them. Each initiative focuses on carefully selected countries and innovations.
Publication date: September 2013; Region: Global; Part of series: Areas of focus fact sheets
33. 2012 Annual Report: Innovation in Motion
PATH’s health solutions touched the lives of more than 118 million people around the world in 2012. Our 2012 annual report highlights our milestones in three focus areas: diarrheal disease and pneumonia; family health; and malaria. It also features innovations in technology development and country‐based health programs, a financial summary, and information about our donors, leadership, and global presence.
Publication date: May 2013; Region: Global; Part of series: Annual reports;
34. Directions in Global Health (Volume 10, Issue 1)
This issue of Directions in Global Health features work by oneWorld Health, PATH’s drug development program, to lead development of innovative methods to enhance the supply of artemisinin, a key ingredient in malaria treatments. It includes a commentary by Dr. Ponni Subbiah, who directs PATH’s drug development efforts. Other articles cover work to improve cervical cancer screening, protect infants from respiratory syncytial virus, increase access to family planning, and strengthen and expand use of human milk banking.
Publication date: May 2013; Region: Global; Part of series:
35. Directions in Global Health PATH Today (Spring 2013)
This issue of PATH Today describes PATH’s multipronged approach to eliminating malaria in
Publication date: May 2013; Region: Global; Part of series: PATH Today;
36. Investing in Malaria Pays Off
This infographic gives a visual representation of the cost‐effectiveness of malaria interventions in
Publication date: 2013; Region: Africa;
This infographic gives a visual representation of PATH’s three‐step approach to test and treat malaria infections: rapid reporting, mass test and treat, and active surveillance.
Publication date: 2013; Region: Africa;
38. A Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Infants
This article, published in the New England Journal of Medicine (NEJM), reports results from a pivotal, large‐scale Phase 3 trial of RTS,S/AS01 malaria vaccine. When compared to immunization with a control vaccine, infants (aged 6 to 12 weeks at first vaccination) vaccinated with RTS,S had one‐third fewer episodes of both clinical and severe malaria and had similar reactions to the injection. In this trial, RTS,S demonstrated an acceptable safety and tolerability profile. The abstract of this article is available through the NEJM by clicking on “Visit web page” below, or for free access to the full lenth article please visit malariavaccine.org and click on “Read the NEJM article.”
Publication date: December 2012; Region: Africa;
39. The PATH Malaria Vaccine Initiative
The PATH Malaria Vaccine Initiative (MVI) is a vaccine development program of PATH. This fact sheet provides an overview of MVI’s history, mission, vision, and work.
Publication date: November 2012; Region: Global ;
This issue of PATH Today leads with the Mama SASHA project, which is improving nutrition, agriculture, and prenatal health care in
Publication date: November 2012; Region: Global; Part of series: PATH Today
Fluorescence In Situ Hybridization (FISH) Assays for Diagnosing Malaria in Endemic Areas. Jyotsna Shah, Olivia Mark, Helena Weltman, Nicolas Barcelo, Wai Lo, Danuta Wronska, Srinivas Kakkilaya, Aravinda Rao, Shalia T. Bhat, Ruchi Sinha, Sabah Omar, Peter O’bare, Manuel Moro, Robert H. Gilman, Nick Harris. PLOS one. September 2, 2015. DOI: 10.1371/journal.pone.0136726. Full Text at http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0136726 [Added: Sep 7, 2015]
A novel multiple‐stage antimalarial agent that inhibits protein synthesis. Baragaña B et al. Nature. 18 June 2015;522:315‐320. doi:10.1038/nature14451 [Abstract] (Added: Jun 18, 2015)
RIFINs are adhesins implicated in severe Plasmodium falciparum malaria. Goel S et al. Nature Medicine. 2015. doi:10.1038/nm.3812. [Abstract] (Added Mar 12, 2015)
Antimalarial drug discovery — approaches and progress towards new medicines. Flannery EL,
Blocking malaria transmission to Anopheles mosquitoes using artemisinin derivatives and primaquine: a systematic review and meta‐analysis. Abay SM. Parasites & Vectors 2013;6:278.[Full Text] (Added Nov 5, 2013)
The complexity of medicinal plants: The traditional Artemisia annua formulation, current status and future perspectives. van der Kooy F, Sullivan SE. Journal of Ethnopharmacology. 28 October 2013;150(1):1‐13.[Abstract] (Added Nov 5, 2013)
The activation of vivax malaria hypnozoites by infectious diseases. Shanks GD,
Dried Whole Plant Artemisia annua as an Antimalarial Therapy. Elfawal MA, Towler MJ, Reich NG, Golenbock D, Weathers PJ, et al. PLoS onE. 2012;7(12):e52746. doi:10.1371/journal.pone.0052746[Full Text] (Added Feb 7, 2013)
Evidence and Implications of Mortality Associated with Acute Plasmodium vivax Malaria. J. Kevin Baird. Clin. Microbiol. Rev. January 2013;26(1):36‐57. doi: 10.1128/?CMR.00074‐12[Abstract] (Added Feb 7, 2013)
Randomized, controlled trial of the long term safety, immunogenicity and efficacy of RTS,S/AS02D malaria vaccine in infants living in a malaria‐endemic region.Abdulla S, Salim N, Tanner M et al. Malaria Journal. 2013;12:11.[Full Text] (Added Feb 7, 2013)
Red blood cell membrane dynamics during malaria parasite egress. Callan‐Jones A et al.Biophys J. 2012 Dec 19;103(12):2475‐83. doi: 10.1016/j.bpj.2012.11.008. Epub 2012 Dec 18.[Abstract] (Added Feb 7, 2013)
Assessment of the Molecular Marker of Plasmodium falciparum Chloroquine Resistance ( Pfcrt) in
Malaria Control and Elimination in
Reduced Risk of Plasmodium vivax Malaria in Papua New Guinean Children with Southeast Asian Ovalocytosis in Two Cohorts and a Case‐Control Study. Rosanas‐Urgell A, Lin E, Manning L, Rarau P, Laman M, et al. PLoS Med. 2012;9(9):e1001305. doi:10.1371/journal.pmed.1001305.[Full Text] (Added Sep 6, 2012)
High levels of DDT in breast milk: Intake, risk, lactation duration, and involvement of gender. Hindrik Bouwmana, Henrik Kylinb, Barbara Seredad, Riana Bornman. Env Pollu. November 2012;170:63‐70.[Abstract] (Added Sep 6, 2012)
Translocation of Sickle Cell Erythrocyte MicroRNAs into Plasmodium falciparum Inhibits Parasite Translation and Contributes to Malaria Resistance. LaMonte G et al. Cell Host & Microbe. 16 August 2012;12(2):187‐199.[Abstract] (Added Aug 30, 2012)
New global estimates of malaria deaths
Targets of antibodies against Plasmodium falciparum‐infected erythrocytes in malaria immunity Chan J et al. J Clin Invest. 2012. doi:10.1172/JCI62182.[Full Text] (Added Aug 14, 2012)
The malaria parasite Plasmodium vivax exhibits greater genetic diversity than Plasmodium falciparum. Neafsey DE et al. Nature Genetics 2012. doi:10.1038/ng.2373[Letter] (Added Aug 14, 2012)
Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing Manske M et al. Nature. 2012. doi:10.1038/nature11174.[Letter] (Added Jun 30, 2012)
Relapse of imported Plasmodium vivax malaria is related to primaquine dose: a retrospective study Townell N et al. Malaria Journal. 2012;11:214 doi:10.1186/1475‐2875‐11‐214.[Full Text] (Added Jun 30, 2012)
New targets, new hope: novel drug targets for curbing malaria.Arora N, Banerjee AK. Mini Rev Med Chem. 2012 Mar;12(3):210‐26.[Abstract] (Added Jun 30, 2012)
Poor‐quality antimalarial drugs in southeast Asia and sub‐Saharan
Haemoglobinopathies and the clinical epidemiology of malaria: a systematic review and meta‐analysis Taylor SM, Parobek CM,
Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum infections Pillai DR et al. Malaria Journal 2012;11:131. [Full Text] (Added Apr 28, 2012)
Plasmodium vivax malaria‐associated acute kidney injury,
Plasmodium vivax Adherence to Placental Glycosaminoglycans. Chotivanich K, Udomsangpetch R, Suwanarusk R, Pukrittayakamee S, Wilairatana P, et al. PLoS onE. 2012;7(4):e34509.[Full Text] (Added Apr 28, 2012)
The anaemia of Plasmodium vivax malaria.
Artemisinin‐based combination therapy does not measurably reduce human infectiousness to vectors in a setting of intense malaria transmission. Huho BJ et al. Malaria Journal. 2012;11:118.[Full Text] (Added Apr 28, 2012)
Malaria resurgence: a systematic review and assessment of its causes. Cohen JM et al. Malaria Journal 2012;11:122.[Full Text] (Added Apr 26, 2012)
Induction of Strain‐Transcending Antibodies Against Group A PfEMP1 Surface Antigens from Virulent Malaria Parasites.Ghumra A, Semblat J‐P, Ataide R, Kifude C, Adams Y, et al. PLoS Pathog. 2012;8(4):e1002665. doi:10.1371/journal.ppat.1002665 [Full Text] (Added Apr 22, 2012)
Toward fast malaria detection by secondary speckle sensing microscopy. Dan Cojoc, Sara Finaurini, Pavel Livshits, Eran Gur, Alon Shapira, Vicente Mico, and Zeev Zalevsky. Biomedical Optics Express. 2012;3(5):991‐1005. [Full Text] (Added Apr 22, 2012)
A global map of dominant malaria vectors. Sinka ME et al. Parasites & Vectors. 2012;5:69. doi:10.1186/1756‐3305‐5‐69 [Full Text] (Added Apr 14, 2012)
Emergence of artemisinin‐resistant malaria on the western border of
A Major Genome Region Underlying Artemisinin Resistance in Malaria. Cheeseman IH et al. Science. 6 April 2012;336(6077):79‐82. DOI: 10.1126/science.1215966. [Abstract] (Added Apr 9, 2012)
Emergence of artemisinin‐resistant malaria on the western border of
Gene selective mRNA cleavage inhibits the development of Plasmodium falciparum. Augagneur Y et al. PNAS. April 2, 2012. doi: 10.1073/pnas.1203516109 [Abstract] (Added Apr 4, 2012)
Risk factors for mortality from imported falciparum malaria in the
Global malaria mortality between 1980 and 2010: a systematic analysis Murray CJL et al. The Lancet. 4 February 2012;379(9814):413‐431. doi:10.1016/S0140‐6736(12)60034‐8 [Full Text] | New estimates of malaria deaths: concern and opportunity The Lancet Editorial. 4 February 2012;379(9814):385. doi:10.1016/S0140‐6736(12)60169‐X [Full Text] (Added Feb 3, 2012)
Evaluation of the antiplasmodial and cytotoxicity potentials of husk fiber extracts from Cocos nucifera, a medicinal plant used in
A new world malaria map: Plasmodium falciparum endemicity in 2010. Gething PW et al. Malaria Journal 2011;10:378 doi:10.1186/1475‐2875‐10‐378 [Abstract] (Added Jan 25, 2012)
Endoplasmic Reticulum PI(3)P Lipid Binding Targets Malaria Proteins to the Host Cell.Souvik Bhattacharjee, Robert V. Stahelin, Kaye D. Speicher, David W. Speicher, Kasturi Haldar. Cell. 20 January 2012;148(1):201‐212. [Abstract] (Added Jan 22, 2012)
Structure of a Potential Antimalarial Drug Target Revealed?: Structure and Reaction Mechanism of Phosphoethanolamine Methyltransferase from Malaria Parasite Plasmodium falciparum. Antiparasitic Drug Target. J. Biol. Chem. 2012;287:1435. [Full Text] (Added Jan 21, 2012)
Clindamycin plus quinine for treating uncomplicated falciparum malaria: a systematic review and meta‐analysis.
The Use of Artemether‐Lumefantrine for the Treatment of Uncomplicated Plasmodium vivax Malaria. Bassat Q. PLoS Negl Trop Dis. 2011;5(12):e1325. doi:10.1371/journal.pntd.0001325 [Full Text] (Added Jan 21, 2012)
Adverse effects of falciparum and vivax malaria and the safety of antimalarial treatment in early pregnancy: a population‐based study McGready R et al. The Lancet Infectious Diseases. doi:10.1016/S1473‐3099(11)70339‐5. [Full Text] (Added Dec 14, 2011)
Rodent blood‐stage Plasmodium survive in dendritic cells that infect naive mice
Plasmodium falciparum Parasites are Killed by a
Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum. Crosnier C et al. Nature 2011. doi:10.1038/nature10606 [Abstract] (Added Nov 11, 2011)
Effects of Artesunate on Parasite Recrudescence and Dormancy in the Rodent Malaria Model Plasmodium vinckei. LaCrue AN, Scheel M, Kennedy K, Kumar N, Kyle DE. PLoS onE 2011;6(10):e26689. doi:10.1371/journal.pone.0026689 [Full Text] (Added Oct 27, 2011)
First Results of Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Children. The RTS,S Clinical Trials Partnership.
Vaccine Platforms Combining Circumsporozoite Protein and Potent Immune Modulators, rEA or EAT‐2, Paradoxically Result in Opposing Immune Responses.
Laboratory demonstration of a prozone‐like effect in HRP2‐detecting malaria rapid diagnostic tests: implications for clinical management Jennifer Luchavez et al. Malaria Journal 2011;10:286 doi:10.1186/1475‐2875‐10‐286 [Full Text] (Added Oct 9, 2011)
Dramatic Decrease in Malaria Transmission after Large‐Scale Indoor Residual Spraying with Bendiocarb in Benin, an Area of High Resistance of Anopheles gambiae to Pyrethroids Martin Akogbeto et al. Am J Trop Med Hyg 2011;85(4):86‐593. doi: 10.4269/ajtmh.2011.10‐0668 [Abstract] (Added Oct 9, 2011)
Net Benefits: A Multicountry Analysis of Observational Data Examining Associations between Insecticide‐Treated Mosquito Nets and Health Outcomes. Lim SS, Fullman N, Stokes A, Ravishankar N, Masiye F, et al. PLoS Med 2011; 8(9):e1001091. doi:10.1371/journal.pmed.1001091. [Full Text] (Added Sep 17, 2011)
Chemical Rescue of Malaria Parasites Lacking an Apicoplast Defines Organelle Function in Blood‐Stage Plasmodium falciparum. Yeh E, DeRisi JL. PLoS Biol 2011;9(8): e1001138. doi:10.1371/journal.pbio.1001138 [Full Text] (Added Sep 5, 2011)
Malaria morbidity and pyrethroid resistance after the introduction of insecticide‐treated bednets and artemisinin‐based combination therapies: a longitudinal study. Trape JF et al. The Lancet Infectious Diseases. 18 August 2011. doi:10.1016/S1473‐3099(11)70194‐3 [Full Text] (Added Aug 22, 2011)
Rerooting the evolutionary tree of malaria parasites.
Resolving the phylogeny of malaria parasites. Rich SM, Xu G. PNAS August 9, 2011;108(32):12973‐12974. doi: 10.1073/pnas.1110141108 [Abstract] (Added Aug 12, 2011)
Ivermectin Mass Drug Administration to Humans Disrupts Malaria Parasite Transmission in Senegalese Villages Kobylinski KC et al. Am J Trop Med Hyg 2011;85(1):3‐5 [Abstract] (Added July 10, 2011)
Efficacy of Aquatain, a Monomolecular Film, for the Control of Malaria Vectors in Rice Paddies. Githeko AK, Koenraadt CJM. PLoS onE 2011;6(6):e21713. doi:10.1371/journal.pone.0021713 [Full text] (Added July 3, 2011)
Consequences of HIV infection on malaria and therapeutic implications: A systematic review. Clara Flateau, Guillaume Le Loup, Gilles Pialoux. The Lancet Infectious Diseases July 2011;11(7):541‐556 [Full text] (Added June 25, 2011)
Plasmodium vivax malaria: Is it actually benign? Harpal Singh, Ankit Parakha, Srikanta Basua, Bimbadarh Ratha. Journal of Infection and Public Health June 2011;4(2):91‐95[Abstract] (Added June 18, 2011)
Safety, pharmacokinetics and efficacy of artemisinins in pregnancy Veronica Ades. Infectious Disease Reports 2011;3(1)37‐43 [Full text] (Added June 18, 2011)
Prozone in malaria rapid diagnostics tests: how many cases are missed? Philippe Gillet et al. Malaria Journal 2011;10:166 doi:10.1186/1475‐2875‐10‐166 [Full text] (Added June 18, 2011)
Plasmodium knowlesi: Reservoir Hosts and Tracking the Emergence in Humans and Macaques. Lee K‐S, Divis PCS, Zakaria SK, Matusop A, Julin RA, et al. PLoS Pathog 2011;7(4):e1002015. doi:10.1371/journal.ppat.1002015. [Full text] (Added Apr 11, 2011)
Activation of a PAK‐MEK signalling pathway in malaria parasite‐infected erythrocytes. Audrey Sicard et al. Cellular Microbiology 4 March 2011. DOI: 10.1111/j.1462‐5822.2011.01582.x [Full text] (Added Mar 10, 2011)
Development of Transgenic Fungi That Kill Human Malaria Parasites in Mosquitoes. Weiguo Fang et al. Science 25 February 2011;331(6020):1074‐1077 DOI: 10.1126/science.1199115 [Abstract | Podcast] (Added Feb 25, 2011)
malERA ‐ a research agenda for malaria eradication on PLoS Medicine [PLoS Collections] (Added Jan 27, 2011)
Super‐Resolution Dissection of Coordinated Events during Malaria Parasite Invasion of the Human Erythrocyte. Riglar DT et al. Cell Host & Microbe. 20 January 2011;9(1):9‐20. Free Full text (Added Jan 21, 2011)
Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open‐label, randomised trial. Arjen M Dondorp et al. The Lancet. Early online Publication, 8 November 2010 doi:10.1016/S0140‐6736(10)61924‐1. Free Full text (Added Nov 9, 2010)
Malaria Elimination: Lancet Special, Oct 29, 2010 (Added Nov 3, 2010)
Widespread Divergence Between Incipient Anopheles gambiae Species Revealed by Whole Genome Sequences MKN Lawniczak, SJ Emrich, AK Holloway et al. Science. 22 October 2010;330(6003):512‐514. Abstract (Added Oct 26, 2010)
The Armadillo Repeat Protein PF16 Is Essential for Flagellar Structure and Function in Plasmodium Male Gametes. Straschil U, Talman AM,
Adult and child malaria mortality in
Chloroquine Clinical Failures in P. falciparum Malaria Are Associated with Mutant Pfmdr‐1, Not Pfcrt in
Severe Imported Falciparum Malaria: A Cohort Study in 400 Critically Ill Adults. Bruneel F, Tubach F, Corne P, Megarbane B, Mira J‐P, et al. PLoS onE 5(10): e13236. doi:10.1371/journal.pone.0013236 Free Full Text (Added Oct 23, 2010)
Distinct Olfactory Signaling Mechanisms in the Malaria Vector Mosquito Anopheles gambiae. Liu C, Pitts RJ, Bohbot JD, Jones PL, Wang G, et al. PLoS Biol 2010;8(8): e1000467. doi:10.1371/journal.pbio.1000467 Free Full Text (Added Sep 2, 2010)
Artemisinin resistant P. falciparum: Can the genie be put back in the bottle Egan TJ. Future Microbiol 2009;4(6)637‐639 Free Full Text (Added Oct 14, 2009)
Proteome Analysis of Plasmodium falciparum Extracellular Secretory Antigens at Asexual Blood Stages Reveals a Cohort of Proteins with Possible Roles in Immune Modulation and Signaling. Meha Singh et al. Molecular & Cellular Proteomics 2009;8:2102‐2118 Abstract (Added Oct 1, 2009)
Reliable enumeration of malaria parasites in thick blood films using digital image analysis John A Frean. Malaria Journal 2009, 8:218 doi:10.1186/1475‐2875‐8‐218 Free Full Text (Added Sep 29, 2009)
Effect of two different house screening interventions on exposure to malaria vectors and on anaemia in children in The
House screening for malaria control John E Gimniga, Laurence Slutsker. The Lancet September 2009;374(9694):954‐955 Free Full Text (Added Sep 29, 2009)
Artemisinin Resistance in Plasmodium falciparum Malaria Arjen M. Dondorp et al. NEJM July 30, 2009;361(5):455‐467 Free Full Text (Added Sep 28, 2009)
Efficacy and safety of intermittent preventive treatment with sulfadoxine‐pyrimethamine for malaria in African infants: a pooled analysis of six randomised, placebo‐controlled trials John J Aponte et al. The Lancet Early online Publication, 17 September 2009doi:10.1016/S0140‐6736(09)61258‐7 Abstract (Added Sep 18, 2009)
Key gaps in the knowledge of Plasmodium vivax, a neglected human malaria parasite Ivo Mueller et al. Lancet Infect Dis September 2009;9(9):555‐566 Abstract (Added Sep 17, 2009)
Synthesis of oxalamide and triazine derivatives as a novel class of hybrid 4‐aminoquinoline with potent antiplasmodial activity Naresh Sunduru et al.Bioorganic & Medicinal Chemistry September 2009;17(17):6451‐6462
Abstract (Added Sep 17, 2009)
Malaria severity status in patients with soil‐transmitted helminth infections. Abraham Degarege et al. Acta Tropica October 2009;112(1):8‐11 Abstract (Added Sep 17, 2009)
Mobile Phone Based Clinical Microscopy for Global Health Applications. Breslauer DN, Maamari RN, Switz NA,
The origin of malignant malaria Stephen M. Rich et al. PNAS www.pnas.org/cgi/doi/10.1073pnas.0907740106 Free Full Text (Added Aug 7, 2009)
Can Prenatal Malaria Exposure Produce an Immune Tolerant Phenotype?: A Prospective Birth Cohort Study in Kenya Indu Malhotra et al. PLoS Med 2009;6(7): e1000116. doi:10.1371/journal.pmed.1000116, Article ID 415953 Free Full Text (Added Aug 5, 2009)
Unraveling the Impact of Malaria Exposure Before Birth Lars Hviid PLoS Med 2009;6(7): e1000117. Free Full Text (Added
Aug 5, 2009)
Protection against a Malaria Challenge by Sporozoite Inoculation
Artemisinin Resistance in Plasmodium falciparum Malaria Arjen M. Dondorp et al. NEJM. 2009;361(5):455‐467 Free Full Text (Added Aug 5, 2009)
Platelets, Pyrexia, and Plasmodia Doron C. Greenbaum, Garret A. FitzGerald NEJM. 2009;361(5):526‐528 Abstract (Added
Aug 5, 2009)
A monkey’s tale: The origin of Plasmodium vivax as a human malaria parasite Ananias A. Escalante et al. PNAS. 2005;102(6):1980‐85 Free Full Text (Added Aug 5, 2009)
Rapid Diagnosis of Malaria Miguel A SanJoaquin,
Comparing Water, Bovine Milk, and Indoor Residual Spraying as Possible Sources of DDT and Pyrethroid Residues in Breast Milk Barbara Sereda, Henk Bouwman, Henrik Kylin ournal of Toxicology and Environmental Health. January 2009 Part A;72(14):897‐908 Abstrat (Added July 1, 2009)
Malaria and vitamin A deficiency in African children: a vicious circle? Miguel A SanJoaquin, Malcolm E Molyneux Malaria Journal. 2009;8:134 doi:10.1186/1475‐2875‐8‐134. Free Full Text (Added June 27, 2009)
The effect of mimicking febrile temperature and drug stress on malarial development Ratchaneewan Aunpad et al. Annals of Clinical Microbiology and Antimicrobials. 2009;8:19 doi:10.1186/1476‐0711‐8‐19. Free Full Text (Added June 27, 2009)
Risk factors for malaria deaths in Jalpaiguri district, West Bengal,
Malaria Diagnosis: A Brief Review Noppadon Tangpukdee, Chatnapa Duangdee, Polrat Wilairatana, Srivicha Krudsood Korean J Parasitol. 2009 Jun;47(2):93‐102. Free Full Text (Added June 16, 2009)
Malarial Hepatopathy in Falciparum Malaria Shahnaz Shah, Liaquat Ali, Rukhsana Abdul Sattar, Tariq Aziz, Tahir Ansari, Jamal Ara Journal of the College of Physicians and Surgeons Pakistan. 2009;19;(6):367‐370. Free Full Text (Added June 16, 2009)
Simulation of the cost‐effectiveness of malaria vaccines Fabrizio Tediosi et al. Malaria Journal. 2009;8:127 doi:10.1186/1475‐2875‐8‐127 Free Full Text (Added June 16, 2009)
Larvicidal activity of neem oil (Azadirachta indica) formulation against mosquitoes Virendra K Dua et al. Malaria Journal. 2009;8:124 doi:10.1186/1475‐2875‐8‐124 Free Full Text (Added June 16, 2009)
Good News in Malaria Control… Now What? Richard W. Steketee. Am. J. Trop. Med. Hyg. 2009;80(6):879‐880. Free Full Text (Added June 9, 2009)
Severe Retinal Whitening in an Adult with Cerebral Malaria. Maude RJ, Hassan MU, Beare NAV. Am. J. Trop. Med. Hyg. 2009;80(6):881. Free Full Text (Added June 9, 2009)
Comparison of Sulfadoxine‐Pyrimethamine, Unsupervised Artemether‐Lumefantrine, and Unsupervised Artesunate‐Amodiaquine Fixed‐Dose Formulation for Uncomplicated Plasmodium falciparum Malaria in
Abstract (Added June 9, 2009)
Adhesion of Plasmodium falciparum‐infected erythrocytes to human cells: molecular mechanisms and therapeutic implications. Rowe JA, Claessens A, Corrigan RA, Arman M. Expert reviews in molecular medicine May 2009; Vol. 11:e16. doi:10.1017/S1462399409001082. Abstract (Added June 9, 2009)
Effect of Malaria Rapid Diagnostic Tests on the Management of Uncomplicated Malaria with Artemether‐Lumefantrine in
Abstract (Added June 9, 2009)
Vivax Malaria: A Major Cause of Morbidity in Early Infancy. Jeanne R. Poespoprodjo et al. Clinical Infectious Diseases 2009;48:1704‐1712. Abstract (Added June 9, 2009)
A New Malaria Agent in African Hominids. Ollomo B, Durand P, Prugnolle F, Douzery E, Arnathau C, et al. PLoS Pathog 2009;5(5): e1000446. doi:10.1371/journal.ppat.1000446. Free Full Text (Added June 3, 2009)
Antimalarial natural products of marine and freshwater origin Karl Gademann, Joanna Kobylinska. The Chemical RecordMay 2009. Abstract (Added June 3, 2009)
Malaria Control Insecticide Residues in Breastmilk: The Need to Consider Infant Health Risks Hindrik Bouwman, Henrik Kylin Env Health PerspMay 2009. Free Full Text (Added June 3, 2009)
Strong Gametocytocidal Effect of Methylene Blue‐Based Combination Therapy against Falciparum Malaria: A Randomised Controlled Trial. Coulibaly B, Zoungrana A, Mockenhaupt FP, Schirmer RH, Klose C, et al. PLoS onE2009;4(5): e5318. doi:10.1371/journal.pone.0005318. Free Full Text (Added June 3, 2009)
Influence of Rapid Malaria Diagnostic Tests on Treatment and Health Outcome in Fever Patients, Zanzibar—A Crossover Validation Study Msellem MI, Mårtensson A, Rotllant G, Bhattarai A, Strömberg J, et al. PLoS Med2009;6(4): e1000070. Free Full Text (Added May 5, 2009)
The Role of Rapid Diagnostic Tests in Managing Malaria. Bisoffi Z, Gobbi F, Angheben A, Van den Ende J. PLoS Med. 2009;6(4): e1000063 Free Full Text (Added May 5, 2009)
Phase 1/2a Study of the Malaria Vaccine Candidate Apical Membrane Antigen‐1 (AMA‐1) Administered in Adjuvant System AS01B or AS02A. Spring MD, Cummings JF, Ockenhouse CF, Dutta S, Reidler R, et al. PLoS onE 2009;4(4):e5254
Free Full Text (Added May 5, 2009)
Towards high‐throughput molecular detection of Plasmodium: new approaches and molecular markers Steenkeste N, Incardona S, Chy S et al. Malaria Journal2009;8:86. Free Full Text (Added May 5, 2009)
The Malaria Severity Score: a Method for Severity Assessment and Risk Prediction of Hospital Mortality for Falciparum Malaria in Adults MK Mohapatra, SP Das. JAPI. 2009;57:119‐126 Free Full Text (Added Feb 10, 2009)
Malarial anemia and STAT6 Robson KJH, Weatherall DJ. Haematologica. 2009;94(2) Free Full Text (Added Feb 10, 2009)
STAT6‐mediated suppression of erythropoiesis in an experimental model of malarial anemia Thawani N, Tam M, Stevenson MM. Haematologica. 2009;94(2):195‐204 Free Full Text (Added Feb 10, 2009)
Probability of emergence of antimalarial resistance in different stages of the parasite life cycle Wirichada Pongtavornpinyo et al. Journal compilation. 2009;52‐61 Free Full Text (Added Feb 10, 2009)
Malarial Retinopathy in Cerebral Malaria Beare NAV, Glover SJ, Molyneux M. Am. J. Trop. Med. Hyg. 2009;80(2):171 Free Full Text (Added Feb 10, 2009)
Methemoglobinemia and Adverse Events in Plasmodium vivax Malaria Patients Associated with High Doses of Primaquine Treatment Jaime Carmona‐Fonseca, Gonzalo Álvarez, Amanda Maestre. Am. J. Trop. Med. Hyg. 2009;80(2):188‐193. Abstract (Added Feb 10, 2008)
Severe Plasmodium vivax Malaria: A Report on Serial Cases from
Artemisinin derivatives versus quinine in treating severe malaria in children: a systematic review PrayGod G, De Frey A, Eisenhut M. Malaria Journal. 2008, 7:210 Free Full Text (Added Oct 28, 2008)
Comparative genomics of the neglected human malaria parasite Plasmodium vivax Carlton JM et al. Nature. 455, 757‐763 (9 October 2008) Free Full Text (Added Oct 24, 2008)
Malaria research in the post‐genomic era Winzeler EA. Nature. 455, 751‐756 (9 October 2008) Abstract (Added Oct 24, 2008)
Burden of Cerebral Malaria in
Biological control of mosquito populations through frogs: Opportunities & constrains Raghavendra K, Sharma P, Dash AP. Indian J Med Res . 2008;128:22‐25 Free Full Text (Added Oct 8, 2008)
Effectiveness of artemisinin‐based combination therapy used in the context of home management of malaria: A report from three study sites in sub‐Saharan
Neurosyphilis, Malaria, and the Discovery of Antipsychotic Agents Frankenburg FR, Baldessarini RJ. Harvard Review of Psychiatry. 2008;16(5):299‐307(37) Abstract (Added Oct 8, 2008)
Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum. Park Y, Diez‐Silva M, Popescu G et al. PNAS. 2008;105(37) Free Full Text (Added Sep 10, 2008)
Platelet Factor 4 Mediates Inflammation in Experimental Cerebral Malaria. Srivastava K,
Presumptive treatment of fever cases as malaria: Help or hindrance for malaria control? Roly D Gosling, Christopher J Drakeley, Alex Mwita, Daniel Chandramohan. Malaria Journal. 2008, 7:132 Full Text at http://www.malariajournal.com/content/pdf/1475-2875-7-132.pdf (Added Jul 28, 2008)
The usefulness of a new rapid diagnostic test, the First Response® Malaria Combo (pLDH/HRP2) card test, for malaria diagnosis in the forested belt of central India Praveen K Bharti, Nipun Silawat, Pushpendra P Singh, Mrigendra P Singh1, Manmohan Shukla, Gyan Chand, Aditya P Dash, Neeru Singh. Malaria Journal. 2008, 7:126 Full Text at
http://www.malariajournal.com/content/pdf/1475-2875-7-126.pdf (Added Jul 28, 2008)
Reduction of transmission from malaria patients by artemisinin combination therapies: a pooled analysis of six randomized trials. Lucy C Okell1, Chris J Drakeley, Azra C Ghani, Teun Bousema, Colin J Sutherland. Malaria Journal. 2008, 7:125 Full Text at http://www.malariajournal.com/content/pdf/1475-2875-7-125.pdf (Added Jul 28, 2008)
Plasmodium falciparum in ancient Egypt. [letter]. Nerlich AG, Schraut B, Dittrich S, Jelinek T, Zink AR. Emerg Infect Dis [serial on the Internet]. 2008 Aug Full Text at http://www.cdc.gov/EID/content/14/8/1317.htm (Added Jul 28, 2008)
Cerebral Malaria in Children Is Associated With Long‐term Cognitive Impairment. John CC, MD, Bangirana P, Byarugaba J et al. PEDIATRICS. Vol. 122 No. 1 July 2008, pp. e92‐e99 Full Text at http://pediatrics.aappublications.org/cgi/content/full/122/1/e92 (Added Jul 14, 2008)
Evaluation of light microscopy and rapid diagnostic test for the detection of malaria under operational field conditions: a household survey in
First Case of Emergence of Atovaquone‐Proguanil (MalaroneTM) Resistance in Plasmodium falciparum During Treatment in Traveller from
Qinghaosu (Artemisinin): The Price of Success
A Malaria Fingerprint in the Human Genome? Daily JP, Sabeti P. NEJM Apr 16, 2008 Full text at http://content.nejm.org/cgi/content/full/NEJMe0801414 (Added Apr 22, 2008)
A magneto‐optic route towards the in‐vivo diagnosis of malaria: preliminary results and pre‐clinical trial data Newman DM, Heptinstall J, Matelon RJ et al. Biophys J Apr 2008. Full text athttp://www.biophysj.org/cgi/rapidpdf/biophysj.107.128140v1 (Added Apr 22, 2008)
Adverse Pregnancy Outcomes in an Area Where Multidrug‐Resistant Plasmodium vivax and Plasmodium falciparum Infections Are Endemic Poespoprodjo JR, Fobia W,Kenangalem E et al. Clinical Infectious Diseases 2008;46:1374‐1381 Abstract at http://www.journals.uchicago.edu/doi/abs/10.1086/586743 (Added Apr 22, 2008)
Dihydroartemisinin—Piperaquine Rescue Treatment of Multidrug‐resistant Plasmodium falciparum Malaria in Pregnancy: A Preliminary Report Rijken MJ, McGready R, Boel ME et al. Am. J. Trop. Med. Hyg. 2008;78(4):543‐545 Abstract at http://www.ajtmh.org/cgi/content/abstract/78/4/543 (Added Apr 22, 2008)
Malaria: progress, perils, and prospects for eradication Greenwood BM, Fidock DA, Kyle DE et al. J. Clin. Invest. 2008;118(4):1266‐1276 Full Text at http://www.jci.org/articles/view/33996 (Added Apr 22, 2008)
Malaria Vector Management: Where Have We Come From and Where Are We Headed? Muturi EJ, Burgess P, Novak RJ. Am. J. Trop. Med. Hyg. 2008;78(4):536‐537. Full Text at http://www.ajtmh.org/cgi/reprint/78/4/536 (Added Apr 22, 2008)
Long‐term field performance of a polyester‐based long‐lasting insecticidal mosquito net in rural
Potent Antimalarial Activity of Histone Deacetylase Inhibitor Analogues Andrews KT,
Inhibition of Efflux of Quinolines as New Therapeutic Strategy in Malaria Maud H, Sandrine A, Christophe R, Jacques B, Bruno P. Current Topics in Medicinal Chemistry. 2008;8(7):563‐578(16) Abstract at http://www.ingentaconnect.com/content/ben/ctmc/2008/00000008/00000007/art00003
Rectal artemisinins for malaria: a review of efficacy and safety from individual patient data in clinical studies. Melba Gomes, Isabela Ribeiro1, Marian Warsame, Harin Karunajeewa, Max Petzold. BMC Infectious Diseases 2008;8:39 Full Text available at http://www.biomedcentral.com/content/pdf/1471-2334-8-39.pdf
Plasmodium‐Induced Inflammation by Uric Acid. Orengo JM, Evans JE, Bettiol E, Leliwa‐Sytek A, Day K, et al. PLoS Pathog 2008;4(3): e1000013. doi:10.1371/journal.ppat.1000013 Full Text available at http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1000013
The Alpha‐Carbonic Anhydrase from the Malaria Parasite and its Inhibition. Jerapan K, Supuran CT. Current Pharmaceutical Design. 2008;14(7):631‐640. Abstract available at http://www.ingentaconnect.com/content/ben/cpd/2008/00000014/00000007/art00005
Long‐term field performance of a polyester‐based long‐lasting insecticidal mosquito net in rural
Increased Plasmodium falciparum Gametocyte Production in Mixed Infections with P. malariae. J. Teun Bousema, Chris J. Drakeley, Petra F. Mens, Theo Arens, Rein Houben, Sabah A. Omar, Louis C. Gouagna, Henk Schallig, Robert W. Sauerwein. Am. J. Trop. Med. Hyg. 2008;78(3):442‐448 Abstract at http://www.ajtmh.org/cgi/content/abstract/78/3/442?etoc
Malaria in Pregnancy in the
Geographical Distribution of Amino Acid Mutations in Plasmodium vivax DHFR and DHPS from Malaria Endemic Areas of











